门静脉营养对大鼠肝切除后肝脏再生的影响  

Theinfluenceofportalnutritiononliverregenerationafterhepatectomyisrats

作　　者：贾乾斌[1] 潘华[2] 侯彩芳[1] 吴言涛[1] 李双庆[1] 汤宇[1] 

机构地区：[1]华西医科大学附属第一医院普外科,成都610041 [2]四川省第一人民医院

出　　处：《中华肝胆外科杂志》2000年第1期30-32,共3页Chinese Journal of Hepatobiliary Surgery

摘　　要：目的　探讨门静脉营养对肝切除后肝脏再生的影响。方法　将Wistar大鼠 40只随机分为 3组 :Ⅰ组不手术 ,自由摄食 ;Ⅱ组 6 5 %肝切除后用中心静脉营养治疗 ;Ⅲ组术后门静脉营养治疗。实验第 3、6日观察肝脏再生反应。结果　Ⅲ组肝重 体重、肝脏再生率、肝细胞有丝分裂率和DNA合成率与Ⅱ组比差异有显著意义 (P <0 0 5 ) ;Ⅱ、Ⅲ组术后胰岛素水平与Ⅰ组差异无显著意义 ,而胰高糖素水平明显升高 (P<0 0 5 ) ,且Ⅲ组明显高于Ⅱ组 (P <0 0 5 ) ,致使Ⅲ组胰岛素 胰高糖素比值明显低于Ⅱ组 (P <0 0 5 ) ,肝脏脂肪变性明显减轻。结论　大鼠肝切除后门静脉营养能降低血胰岛素 胰高糖素比值 ,减轻肝脏脂肪变性 ,促进肝脏再生。Objective Thisstudywasdesignedtoinvestigatetheeffectofportalnutritiononliverregener ationafter 6 5 %hepatectomy.Methods Theratswereallocatedrandomlytooneofthreegroups(G) :ratsinGⅠ receivedstandardfodderadlibitumandweredevoidofhepatectomy ;inGⅡreceivedparenteralnutritionviacen tralveinafter 6 5 %liverresection ;andinGⅢreceivedthesameparenteralnutritionviaportalveinafterhepatec tomy .Theresponseofliverregenerationwasinvestigatedonthethirdandsixthdayafterliverresection .Results InGⅢ ,thehepaticmassindex ,rateofliverregeneration ,DNAsynthesis,andmitoticindexwereincreasedsig nificantlythanthoseinGⅡ (P <0 .0 5 ) .ThelevelofseruminsulininGⅡandGⅢwasnotincreasedobvious ly ,butthevalueofglucagonwasincreasedsignificantlythanthatinGⅠ (P <0 .0 5 ) ,alsotheglucagoninGⅢ wasincreasedsignificantlythanthatinGⅡ (P <0 .0 5 )andthesteatosisofliverwasreducedobviously .Conclu sions Portalnutritiondecreasedobviouslytheratioofinsulintoglucagonandreducedsteatosiscouldenhanceliver regenerationafterhepatectomy .

关 键 词：门静脉营养 肝脏再生 肝切除术 大鼠 

分 类 号：R605[医药卫生—外科学]