有血管源性危险因素的患者中认知功能障碍发病情况及其危险因素的调查研究  

Incidence and risk factors of cognitive impairment in patients with vascular risk factors

作　　者：张允岭[1] 金香兰[1] 南一楠[1] 郑硕[1] 何婷[1] 郭蓉娟[1] 牛焕敏[1] 薛斐然[1] 傅晨[1] 白文[2] 戴中[2] 赵建军[3] 曹晓兰[4] 张玉莲[5] 陈志强[6] 

机构地区：[1]北京中医药大学东方医院,北京100078 [2]北京大学人民医院 [3]长春中医药大学第一附属医院 [4]山东中医药大学附属医院 [5]天津中医药大学第二附属医院 [6]河北医科大学中医院

出　　处：《北京中医药大学学报（中医临床版）》2012年第1期25-27,共3页Journal of Beijing University of Traditional Chinese Medicine

基　　金：2008年中医药行业科研专项(No.200807011);2010年中医药行业科研专项(No.201007002);北京市新医药学科群建设项目(No.XK100270569);211工程重点学科建设项目资助;北京中医药大学创新团队(No.2011-CXTD-23)

摘　　要：目的利用认知障碍自我辨识、筛查工具在社区、门诊中对有血管源性危险因素的患者进行筛查,探讨认知功能障碍的发病情况及其危险因素,为早期辨识血管源性认知障碍(VCI)提供依据。方法采用国际公认的简易精神状态检查量表(MMSE)和蒙特利尔认知评估量表(MoCA)作为诊断依据,将610例有血管源性危险因素的患者分为认知正常组、轻度认知障碍组(mVCI组)、痴呆组(VD组),分析认知功能障碍的发病情况及其危险因素。结果 610例中认知正常组230例,mVCI组215例,VD组165例。610例中有认知障碍的患者380例,占62.3%。对3组性别分布进行卡方检验,P>0.05,说明各组内男女比无明显差异。对3组年龄进行方差分析,P<0.01,差异有统计学意义。结论筛查中发现多数患者存在不同程度的认知功能障碍,说明对有血管源性危险因素的患者进行认知功能的早期辨识筛查意义重大。有血管源性危险因素的患者中性别不是发生认知功能障碍的危险因素,年龄是发生认知功能障碍的危险因素之一。Objective To screen the patients with vascular risk factors from clinic by applying self-identification and screening stools, discuss the incidence and risk factors of cognitive impairment, and provide evidence for early identification of vascular cognitive impairment （VCI）. Methods Taking Mini-Mental State Examination （MMSE） and Montreal Cognitive Assessment （MoCA） as diagnosis basis, 601 patients with vascular risk factors were divided into normal group, mild cognitive impairment group （mVCI group） and vascular dementia group （VD group）. The incidence and risk factors of cognitive impairment were analyzed. Results Among 601 patients, 230 in normal group, 215 in mVCI group and 165 in VD group. There were 380 patients with cognitive impairment in 610 patients （62.3%）. The sexual distribution was treated with chi-square test in three groups and results showed no significant difference in ratio of male and female （P〉0.05）. The age distribution was treated with variance analysis and the result showed a statistical significance （P〈0.01）. Conclusion The screening has found that most of patients have cognitive impairment in varying degrees, which indicates it is very important that early identification and screening for cognitive function in the patients with vascular risk factors. The sex was not risk factor but age is one of risk factors in the patients with vascular risk factors.

关 键 词：血管源性 危险因素 认知功能障碍 

分 类 号：R259[医药卫生—中西医结合]