维持性血液透析患者的25(OH)D水平及相关分析  

Level of Vitamin D of maintanance hemodialysis patients

作　　者：卞维静[1] 张凌[1] 李文歌[1] 

机构地区：[1]卫生部中日友好医院肾内科

出　　处：《临床药物治疗杂志》2012年第1期8-11,共4页Clinical Medication Journal

基　　金：北京市首都医学发展科研基金研究资助项目(项目编号:2009-3023)

摘　　要：目的了解血液透析患者血清25(OH)D的水平及相关因素。方法选择维持性血液透析治疗>1年、未进行维生素D制剂治疗的患者,对血清25羟维生素D[25(OH)D]、全段甲状旁腺激素(iPTH)、骨特异碱性磷酸酶(BAP)、总钙(矫正钙,Ca)、磷(P)、白蛋白(Alb)及二氧化碳结合力(CO2CP)进行检测及相关分析。结果共入选48例患者,男性30例、女性18例;平均年龄58.7±12.4岁;平均透析龄40.4±50.7个月。25(OH)D的平均水平为41.23±16.41nmol.L-1,低于正常值47.7nmol.L-1的患者占70.8%(34/48)。单因素分析显示,25(OH)D的水平与Alb的水平呈显著的正相关(P<0.05);与年龄、透析龄、iPTH、BAP、Ca、P及CO2CP皆无相关性。结论 25(OH)D在大多数血液透析患者是低下的,与Alb的水平相关;与年龄、iPTH、BAP、Ca及CO2CP无相关性。Objective To evaluate the value of 25 （OH） vitaminD l 25 （OH） D ] in hemodialysis patients. Methods 48 cases of maintanance hemodialysis patients who havent received therapy of vitamin D （Vit D） were enrolled in this clinical trial. Cross -section analysis of serum 25 （OH）D, intact PTH （iPTH）, bone specific alka- line phosphatase（BAP）, calcium（Ca）, phosphorus（P）, albumin（AIb）and CO2CP were performed. Results 48 patients including 30 males and 18 females, average age was 58.7 ± 12.4 years, average dialysis treatment period was 40.4 ± 50.7 monthes, the level of 25 （OH） D was 41.23 ± 16.41 nmol/L, there were 34 cases （70.8% of all patients） whose 25 （OH）D level were≤47.7nmol/L. single corralated analysis showed that 25（OH） D was only positive related with AIb（ P 〈0.05） ; however it had no significant related with age, dialysis time, iPTH, BAP, Ca, P and CO2 CP. Conclusion The level of 25 （OH） D is rather lower in most hemodialysis patients. It has only significant correlation with AIb, and no correlation with age、 iPTH,BAP,及 CO2CP.

关 键 词：25(OH)D 血液透析 全段甲状旁腺激素 骨特异碱性磷酸酶 慢性肾脏病 

分 类 号：R692.5[医药卫生—泌尿科学] R977.24[医药卫生—外科学]