先兆早产患者宫颈粘液6-酮-PGF1α、TXB_2变化与硫酸镁疗效的关系  

Relationship Between the Alteration of 6 keto PGF1α and TXB_2 in Cervical Mucus of Patients with Threatened preterm Labor and the Efficacy of Magnesium Sulfate Treatment

作　　者：曾蔚越[1] 张明[2] 

机构地区：[1]华西医科大学附属第二医院妇产科,成都610041 [2]天津市第一中心医院妇产科

出　　处：《华西医科大学学报》2000年第1期62-64,共3页Journal of West China University of Medical Sciences

基　　金：四川省科委科研基金!资助项目 (资助号 G0 12 5 )

摘　　要：为观察先兆早产患者硫酸镁治疗前后宫颈粘液 6 -酮 - PGF1 α、TXB2 变化与疗效的关系 ,探讨其能否作为判断早产疗效及预后的指标 ,采用放射免疫法检测 2 8例先兆早产患者在硫酸镁治疗前后宫颈粘液 6 -酮 -PGF1α和 TXB2 水平。结果 :治疗成功的患者其宫颈粘液 6 -酮 - PGF1α与 TXB2 水平较治疗前明显下降 (P<0 .0 1 ) ,6 -酮 - PGF1 α与 TXB2 比值明显升高 (P<0 .0 0 1 ) ;治疗失败的患者其宫颈粘液 6 -酮 - PGF1 α和 TXB2 水平较治疗前明显升高 (P<0 .0 1 ) ,6 -酮 - PGF1 α与 TXB2 比值明显降低 (P<0 .0 0 1 )。由此提示 :先兆早产患者在硫酸镁治疗前后的宫颈粘液 6 -酮 - PGF1 α和 TXB2 水平及其比值有明显变化 。This study was conducted to observe the relationship between the alteration of 6 keto PGF1α and TXB 2 in cervical mucus of patients with threatened preterm labor and the efficacy of magnesium sulfate treatment, and to examine whether they could act as markers of efficacy and prognosis in treatment of preterm labor. Cervical mucus was collected from 28 patients with threatened preterm labor before and after magnesium sulfate treatment, the levels of 6 keto PGF1α and TXB 2 were determined by radioimmunoassay (RIA). The results showed that the levels of 6 keto PGF1α and TXB 2 decreased in patients successfully treated with magnesium sulfate ( P <0.01), and the ratio of 6 keto PGF1α to TXB 2 increased significantly ( P <0.001). The levels of 6 keto PGF1α and TXB 2 increased in patients with failed magnesium sulfate treatment ( P <0.01), and the relevant ratio decreased significantly ( P <0.001). The results indicate that the levels of 6 keto PGF1α and TXB 2 in the cervical mucus of patients with threatened preterm labor may change significantly before and after magnesium sulfate treatment and they could be used as markers of efficacy and prognosis in treatment of preterm labor.

关 键 词：先兆早产 PGI2 TXB2 宫颈液 硫酸镁 

分 类 号：R714.21[医药卫生—妇产科学]