2010年山东省人群甲型H1N1流感抗体血清学调查分析  

Serological survey of pandemic influenza A(H1N1) antibodies among healthy individuals in Shandong Province in 2010

作　　者：张圣洋[1] 林艺[1] 王爽[1] 任艳艳[1] 刘倜[1] 王宇路[1] 宋绍霞[1] 李忠[1] 王显军[1] 徐爱强[1] 毕振强[1] 

机构地区：[1]山东省疾病预防控制中心病毒所,山东济南250014

出　　处：《中国病原生物学杂志》2012年第1期10-13,共4页Journal of Pathogen Biology

基　　金：山东省科技厅计划项目(No.2009GG10002054)

摘　　要：目的了解2010年山东省人群甲型H1N1流感感染状况,为制定防控对策提供依据。方法以一般人群为调查对象开展个案调查,并采集血液标本,采用血凝抑制试验(HI)进行甲型H1N1流感病毒抗体检测,HI抗体滴度≥1︰40判为阳性。结果共调查13 602人,HI检测甲型H1N1流感抗体阳性3 219人,阳性率23.67%;2010年1月、3月和8月抗体阳性率分别为26.72%、18.42%和25.80%;人群流感抗体阳性率年龄、职业及区间差异有统计学意义(P<0.05)。结论山东省人群H1N1流感免疫保护水平有限,早期注射流感疫苗是保护重点人群的有效途径。Objective To explore the status of infection with pandemic influenza A（H1N1） among healthy individuals in Shandong in 2010 and provide evidence to develop a strategy to prevent and control the disease.Methods Multistage-stratified random sampling was used to select subjects who met eligibility criteria,serum samples were collected,and subjects were administered a standardized questionnaire.Antibody response to pH1N1 was measured using a hemagglutination inhibition（HI） assay and a pH1N1 antibody HI titer ≥40 was considered positive.Results In all,13 602 individuals were surveyed and 3 219 individuals tested positive.Overall,individuals tested positive for pandemic influenza A（H1N1） antibodies at a rate of 23.67%.Individuals tested positive for pandemic influenza A（H1N1） antibodies at a rate of 26.72% in January,18.42% in March,and 25.80% in August.There were statistically significant differences in positivity for pandemic influenza A（H1N1） antibodies in different districts,age groups,and professions.Conclusion Subjects from Shandong Province had limited immunity from pandemic influenza A（H1N1）.Early vaccination should be used to reduce the harm to high risk groups.

关 键 词：甲型H1N1流感 感染状况 血清学调查 山东省 

分 类 号：R373[医药卫生—病原生物学]