锌、硒、锗对小鼠免疫功能的影响  

Effect of zinc, selenium and germanium on the immunity of mice

作　　者：薛晚利[1] 何立端[2] 李选社[1] 郝炳华[1] 张志宝 陈楚天 

机构地区：[1]西安医科大学公共卫生学院卫生微生物学及免疫学教研室,西安710061 [2]西安医科大学附属卫生学校 [3]公共卫生学院

出　　处：《西安医科大学学报》2000年第1期16-17,58,共3页Journal of Xi'an Medical University(Chinese)

摘　　要：用灌胃法观察了微量元素锌、硒、锗对小鼠免疫功能的影响。结果 :锌 (8mg/ kg)、硒 (0 .1mg/kg)、锗 (10 0 mg/ kg)均可显著提高小鼠巨噬细胞吞噬百分率及吞噬指数 ,且加锌组较加锗组的作用更为明显 (P <0 .0 1) ;亦可显著提高小鼠 E-花结形成、淋巴细胞增殖反应和 IL - 6活性 (P <0 .0 1)。各实验组之间无明显差异。提示 :适量的锌、硒、锗可提高机体巨噬细胞吞噬功能 ,增强细胞免疫功能和IL - 6活性。The immunity of mice was examined after they were given proper zine (Zn), selenium (Se) and germanium (Ge). The results showed that Zn (8mg/kg), Se (0.1mg/kg), Ge (100mg/kg) all could improve phagocytosis rate of macrophagocyte and phayocytosis index of mice, and at the same time, the effect in Zn group was higer than that in Ge group (P<0.01). In addition, Zn, Se, Ge could raise the erythrocyte rosette formation rate (P<0.01), promote lymphocyte transformation rate (P<0.01) and elevate the activity levels of IL 6 (P<0.01), while there were no difference among each group (P>0.05). These results indicate that appropriate Zn, Se and Ge concentration can enhance the immunity of cells.

关 键 词：微量元素 免疫功能 小鼠 锌 硒 锗 

分 类 号：Q581[生物学—生物化学] R392[医药卫生—免疫学]