妊高征患者血浆肿瘤坏死因子和血管内皮生长因子变化及意义  

Change and significance of plasma tumor necrosis factor - alpha and vascular endothelial growth factor in pregnancy- induced hypertension

作　　者：闻安民[1] 陈颜芳[1] 张斌[1] 程新旺[1] 王智琼[1] 

机构地区：[1]广东省人民医院妇产科,510080

出　　处：《广东医学》2000年第2期119-120,共2页Guangdong Medical Journal

摘　　要：目的测定妊高征患者血浆中肿瘤坏死因子（ｔｕｍｏｒ ｎｅｃｒｏｓｉｓ ｆａｃｔｏｒ， ＴＮＦ）和血管内皮生长因子（ｖａｓｃｕ－ｌａｒ ｅｎｄｏｔｈｅｌｉａｌ ｇｒｏｗｔｈ ｆａｃｔｏｒ， ＶＥＧＦ）水平的变化及意义。方法采用双抗体夹心 ＥＬＩＳＡ法（酶联免疫法）测定妊高征患者（妊高征组）和正常妊娠妇女（对照组）产前血浆ＴＮＦ－α和ＶＥＧＦ水平。结果妊高征组血浆ＴＮＦ－α水平［（８６±２４）ｐｇ／ｍｌ］明显高于对照组［（４７±１６）ｐｇ／ｍｌ（Ｐ＜０．０１）；而血浆ＶＥＧＦ水平妊高征组［（２２±１０）ｐｇ／ｍｌ］则明显低于对照组［（３９±１５）ｐｇ／ｍｌ（Ｐ＜０．０１）。结论妊高征患者血浆中 ＴＮＦ－α异常升高和ＶＥＧＦ异常降低，可能是妊高征时血管内皮细胞功能异常及妊高征发病中的重要环节之一。Objective To evaluate changes and singificance of tumor necrosis factor - alpha (TNF - a) and vascular endothelial growth factor (VEGF) plasma concentrations in patients with pregnancy - induced hypertension (PIH). Methods Plasma TNT- α and VEGF concentrations in patients with PIH (PIH group) and in normal pregnant women (control group) were measured by ELISA. Results Plasma levels of TNF - α were significantly higher in the PIH group [ (86 ± 24)pg/ml than those in the control group[(47 ± 16)pg/ml] (P < 0.01); Meanwhile, plasma levels of VEGF were significantly lower in the PIH group [ (22 ± 10)pg/ml] than those in the control group [ (39 ± 15)pg/ml] (P < 0.01 ), demonstrating there existed a reciprocal abnormality of plasma levels of TNF- α and VEGF in PIH patients. Conclusion Plasma levels of TNF - α are significantly higher and levels of VEGF are significantly lower in PIH patients, which may be associated with vascular endothelial cells dysfunction and may play a crucial role in the pathogenesis of PIH.

关 键 词：肿瘤坏死因子 VEGF 妊娠高血压 综合征 

分 类 号：R714.246[医药卫生—妇产科学]