血清胱抑素对早期糖尿病肾病诊断价值  

Cystatin C Test for the Diagnosis of early Diabetic Nephropathy

作　　者：谢毅娟[1] 陈雪梅[1] 张伟雯[1] 

机构地区：[1]广州医学院第三附属医院,广东广州510150

出　　处：《河北医学》2012年第2期147-149,共3页Hebei Medicine

摘　　要：目的:探讨血清胱抑素(SCysC)在早期糖尿病肾病的诊断价值。方法:选择临床确诊为早期糖尿病肾病(DN)患者144例(早期糖尿病肾病组)和健康人群91名(健康对照组),分别采用采用放射免疫分析法(RIA法)检测其尿微量白蛋白(U-mAlb);采用免疫比浊法检测SCysC;采用碱性苦昧酸法检测血肌酐(SCr)。并对测定结果进行统计学分析。结果:早期糖尿病肾病组尿白蛋白排泄率(UAER)和SCysC指标显著高于健康对照组(P<0.05);而SCr水平和健康对照组比较,并无显著差异(P均>0.05);SCysC在早期糖尿病肾病的诊断中,敏感度为71.5%,特异度为73.0%;而SCr的敏感度为55.6%,特异度为57.3%。结论:SCysC是一个很好的预测和诊断早期糖尿病肾病的指标。其对早期糖尿病肾病的诊断效能优于SCr。Objective： To study the value of the serum Cystatin C（SCysC） in the diagnosis of early diabetic nephropathy.Method： Random selection of 144 patients with early diabetic nephropathy and 91 healthy people were divided into the early diabetic nephropathy group and the health people group（control group）.The level of U-mAlb was detected by radioimmunoassay（RIA）,SCysC was measured by immunoturbidimetry（ITM）,Serum creatinine（SCr） was measured by alkaline picric acid method.And the statistic study has been made to evaluate the results.Result：The UAER and SCysC level of the early diabetic nephropathy group were significantly higher than the control group（P0.05）.There was no significant difference between the early DN group and the control group in terms of SCr（P0.05）.The sensitivity of SCysC to diagnose early diabetic nephropathy was 71.5%,the specificity was 73.0%.But SCr was 55.6% and 57.3% respectively.Conclusion： SCysC is a good indicator for the prediction and diagnosis of incipient DN.SCysC have a higher dignostic ability for the diagnosis of Early Diabetic Nephropathy than SCr.

关 键 词：胱抑素 血肌酐 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]