手性农药毒性评价进展  

Progress in potential toxicity of chiral pesticides

作　　者：刘维屏[1] 张颖[1] 

机构地区：[1]浙江大学环境与资源学院环境科学研究所,浙江杭州310058

出　　处：《浙江大学学报（农业与生命科学版）》2012年第1期63-70,共8页Journal of Zhejiang University:Agriculture and Life Sciences

基　　金：国家杰出青年科学基金资助项目(20225721);国家自然科学基金资助项目(30771255)

摘　　要：长期以来,手性农药都被当作单一化合物进行环境行为和生态毒性研究,但是由于手性农药对映体与生物大分子相互作用的立体选择性,手性农药对动物及人类的毒性作用可能具有对映体选择性.本文介绍了有机磷、有机氯、拟除虫菊酯、苯基吡唑等手性农药对内分泌、神经、免疫、生殖、发育等毒性作用的对映体选择性,分析了对映体选择性产生的机制,在此基础上提出了未来的研究方向.In the past,chiral pesticides were explored as racemic mixtures in environmental fate and ecotoxicities.However,as a result of the enantioselective interactions with chiral molecules,the enantiomers of chiral pesticides may have different potential toxicities to humans and animals.The present review introduced recent findings on enantioselective endocrine disruption,neurotoxicity,immunotoxicity,reproductive and developmental toxicity of organophosphorus,organochlorines,pyrethroids and phenylpyrazole pesticides,as well as the underlying mechanisms.Furthermore,the developmental trends of future investigations were discussed.

关 键 词：手性农药 对映体选择性 内分泌干扰 神经毒性 免疫毒性 发育毒性 毒性机制 

分 类 号：S481[农业科学—农药学]