高压氧治疗早发型重度子痫前期对新生儿体重的影响  

Therapeutic Effect of Hyperbaric Oxygen on Body Weight of Neonates with Earlier Onset Severe Pre-eclampsia

作　　者：辛芳[1] 索青霞 赵春梅[1] 杨彩凤[1] 刘巍[1] 刘秀芹[1] 王淑琴[1] 

机构地区：[1]河北省保定市第二中心医院,河北保定071000 [2]保定市妇幼保健院

出　　处：《实用预防医学》2012年第2期221-222,共2页Practical Preventive Medicine

摘　　要：目的评价高压氧治疗早发型重度子痫前期对新生儿体重的影响。方法 40例单胎初产早发型重度子痫前期孕产妇按照随机数字法平均分为两组,治疗组20例孕产妇采用高压氧治疗,同时给予静滴25%硫酸镁,口服拉贝洛尔及安定;对照组20例孕产妇采用鼻塞给氧,同时给予静滴25%硫酸镁,口服拉贝洛尔及安定。比较两组孕产妇分娩新生儿体重及5 min Apgar评分,评价两组新生儿死亡率。结果治疗组新生儿体重(2.3±0.5)kg显著高于对照组(1.5±0.3)kg,两组比较,差异有统计学意义(t=2.97,P<0.05)。治疗组新生儿5 min Apgar评分≥7分者(17例)显著多于对照组(11例),两组比较,差异有统计学意义(χ2=11.35,P<0.01)。治疗组新生儿死亡率(5%,1/20)显著低于对照组(30%,6/20),差异有统计学意义(χ2=6.20,P<0.05)。结论高压氧综合治疗早发型重度子痫前期可明显增加新生儿体重,提高新生儿存活率,改善母婴预后,值得临床推广使用。Objective To evaluate the curative effect of hyperbaric oxygen therapy on the body weight of neonates with earlier onset severe pre-eclampsia. Methods A total of 40 single birth primiparity puerperae with earlier onset severe pre- eclampsia were randomly divided into two groups （each n = 20）. The treatment group was received hyperbaric oxygen therapy, additionally given 25 % MgSO4 intravenous guttae and orally administered with labetatol and diazepam. The control group was given oxygen inhalation through a nasal catheter, additionally received 25 % MgFK）4 intravenous guttae and administered orally with labetalol and diazapam. The body weight of neonates, 5 rain Apgar scores and the neonatal mortalities of the two groups were compared. Results The body weight of neonates in the treatment group （2.3 ± 0.5 ） kg was statistically higher than that of the control group （ 1.5 ± 0.3） kg, and the difference was statistically significant between the two groups （ t = 2.97, P 〈 0.05）. The number of neonates with 5 rain Apgar score ~7 in the treatment group, was more than that of the control group, there were statistically sign.ificant differences between the two groups （X^2 = 11.35, P〈 0.01）. The neonatal mortality of the treatment group （5 %, 1/20） was significantly lower than that of the control group （30 %, 6,/20）, and the difference was statistically significant （X^2 = 6.20, P 〈 0.05）. Conclusions Hyperbaric oxygen comprehensive therapy in earlier onset severe pre - eclampsia can significantly increase the body weight of neonates, improve neonatal survival rate and the prognoses of both puer- perae and neonates, thus it is worthy of being extensively applied in clinical practice.

关 键 词：重度子痫前期 早发型 高压氧 新生儿 胎儿生长受限 

分 类 号：R714.245[医药卫生—妇产科学]