LC-MS在药物有关物质分析中的应用  

Application of liquid chromatography-mass spectrometry in drug related substances analysis

作　　者：高明[1] 颜晓丹[1] 金松子[2] 蒋庆峰[2] 

机构地区：[1]天津中医药大学,天津300193 [2]天津药物研究院分析测试中心,天津300193

出　　处：《药物评价研究》2012年第1期63-66,共4页Drug Evaluation Research

摘　　要：液质联用技术以其高分离能力、高分辨率和专属性强的优势,在药物分析等方面得到广泛的应用。主要从串联四极杆质谱仪、四极离子阱质谱仪、四极杆-飞行时间质谱仪方面总结近年来液质联用技术在药物有关物质分析方面的应用。Liquid chromatography-mass spectrometry is regarded as an important technology for many advantages such as high separating efficiency, good sensitivity, and strong specificity. So it is widely used in analysis of drugs and metabolites, chemical medicine mixed illegally in Chinese medicine and drug residues. This paper briefly reviewed its application in drug related substances analysis from Quadrupole Mass Spectrometer, Quadrupole Ion Trap Mass Spectrometer, and Quadrupole-Time of Flight Mass Spectrometer.

关 键 词：液质联用技术 质谱:药物分析 有关物质 

分 类 号：R917[医药卫生—药物分析学]