泛素-蛋白酶体系统在心肌保护中的作用  

Role of ubiquitin-proteasome system in myocardial protection

作　　者：贺亮[1] 徐军美 

机构地区：[1]中南大学湘雅二医院麻醉科,长沙410011

出　　处：《国际麻醉学与复苏杂志》2012年第3期186-189,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：背景泛素-蛋白酶体系统（ubiquitin-proteasome system，UPS）在蛋白质的降解和许多细胞进程的调控中都起着重要的作用。近来的研究提出心肌中的UPS对心肌的许多病理变化起到了一定的调控作用。目的探讨UPS在心肌细胞的缺血／再灌注损伤（ischemia-reperfusion injury，IRI）时功能的变化及在各种预处理所产生的心肌保护作用中所起到的作用。内容拟通过IRI对UPS的选择性抑制作用，使用UPS抑制剂和缺血预处理、吸入麻醉药物预处理对UPS功能的保护作用等方面来描述UPS在心肌保护中的作用。趋势目前对于如何合理调控UPS的功能才能更好地起到心肌保护作用依然存在争论。Background The ubiquitin-proteasome system （UPS） is one of the major non-lysosomal pathways for intraeellular degradation of proteins and plays a significant role in regulating many cellular processes. It was reported recently that UPS regulates importantly many cardiac pathological conditions also. Objective UPS dysfunction was found to be associated with myocardial ischemia-reperfusion injury （IRI）. However, the role of UPS in myocardial protection remained controversial. Content The studies about the role of UPS in myocardial ischemia, the effect of proteasome inhibitors in myocardial protection and the effects of ischemic preconditioning and volatile anaesthetics preconditioning on UPS were reviewed. Trend It＇s obvious that further understanding of UPS myocardial protection on IRI needs additional investigation.

关 键 词：泛素-蛋白酶体系统 心肌保护 

分 类 号：R614[医药卫生—麻醉学]