糖尿病对心肌预／后处理效应的影响及机制  

Effects and cellular mechanisms of diabetes mellitus on myocardial preeonditioning/postconditioning

作　　者：陈巧玲[1] 顾尔伟[1] 

机构地区：[1]安徽医科大学第一附属医院麻醉科,合肥230022

出　　处：《国际麻醉学与复苏杂志》2012年第3期194-198,共5页International Journal of Anesthesiology and Resuscitation

摘　　要：背景大量研究已经证实预处理和后处理对正常心脏有保护作用。糖尿病是缺血性心脏病独立的高危因素，对长期预后不利。同时现有研究大多表明糖尿病能干扰心肌保护机制，进而减弱心肌保护效应。目的综述糖尿病对心肌预，后处理效应的影响及机制的研究进展，使人们能系统了解糖尿病对心肌预／后处理效应的影响及可能的机制。内容主要从糖尿病对心血管病的影响；糖尿病对心肌缺血，再灌注的影响；糖尿病对心肌预／后处理效应的影响及机制等方面展开阐述。趋向目前糖尿病对心肌预／后处理效应的影响还存在争议，且具体机制也尚未明确，还需进一步研究来证实，通过前驱大量研究积极寻找糖尿病患者心肌保护的理想药物，提高患者预后和生存率。Background Various studies revealled that preconditioning and postconditioning protect the heart against myocardial ischemic/reperfusion injury. Diabetes mellitus is an independent high risk factor to ischemic heart disease and aggravates the long-term outcome. Recent studies found that diabetes mellitus might impair myocardial protective effects by blocking myocardial preservation mechanisms. Objective This review focused on the effects of diabetes mellitus on myocardial preconditioning/post- conditioning and its possible mechanisms. Content The possible mechanisms includ the influence of diabetes mellitus on cardiovascular disease, the effects of diabetes mellitus on myocardial ischemic/reperfusion injury as well as the effects of diabetes mellitus on myocardial preconditioning/posteonditioning and the possible mechanisms. Trend Though the impact of diabetes mellitus on myocardial preconditioning/postconditionging is controversial and the cellular mechanisms remains unclear, the improvement of the outcome and survival rate of diabetes patients and the exploration of ideal protective cardio agents still needs further studies..

关 键 词：糖尿病 心肌保护 缺血 再灌注 缺血预处理 缺血后处理 

分 类 号：R614[医药卫生—麻醉学]