胃康复治疗脾虚证胃癌前病变的疗效及其作用机理的研究  

Therapeutic Effect or Weikangfu on Gastric Precancerous Disorder with Spleen Deficiency Syndrome and Its Effect of Gastric Mucosal Zinc, Copper, Cyclic Adenosine Monophosphate, Superoxide Dismutase, Lipid Peroxide and 3H-TdR Lymphocyte Conversion

作　　者：尹光耀[1] 张武宁[2] 李国成[3] 黄继人[1] 陈一[1] 何雪芬[1] 戴建良[1] 沈小静[1] 

机构地区：[1]江苏省无锡市第三人民医院,江苏214041 [2]复旦大学国家微分析中心 [3]同济医科大学

出　　处：《中国中西医结合杂志》2000年第3期176-179,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的：观察胃康复冲剂治疗胃粘膜肠化生（ＩＭ）和不典型增生（ＡＴＰ）的临床疗效及其作用机理。方法：中西医证病结合，辨证施治，随证加减应用胃康复冲剂作为治疗组（６１例），不予辨证皆用胃苏冲剂作为对照组（５４例），另设健康对照组（１５名）。治疗前后均作胃镜检查，取胃窦部粘膜作病理诊断、组织化学染色进行肠化生分型、胃粘膜 Ｚｎ、Ｃｕ、ｃＡＭＰ、ＳＯＤ和血清ＬＰＯ３、3Ｈ－ＴｄＲ ＬＣＴ检测。结果：（１）治疗组的症状疗效和病理疗效明显优于对照组（ Ｐ＜ ０．０５， Ｐ＜ ０．０１）。（２）治疗组疗前的胃粘膜 Ｚｎ、 Ｃｕ、 ｃＡＭＰ、ＳＯＤ和３Ｈ－ＴｄＲ ＬＣＴ均较健康对照组低；治疗后均有提高；血清ＬＰＯ治疗后则随之降低，以上变化均有显著性差异（Ｐ＜０．０５，Ｐ＜０．０１）。结论：胃康复冲剂逆转ＩＭ和ＡＴ Ｐ，是通过改善胃粘膜Ｚｎ、Ｃｕ、ｃＡＭＰ和ＳＯＤ的水平，促进细胞分化，提高细胞免疫功能，降低氧自由基和ＬＰＯ的机制实现的。To observe the clinical therapeutic effect of Weikangfu granule (WKF) on intestinal metaplasia (IM), atypical proliferation (ATP) and its therapeutic mechanism. Methods: Sixty-one patients (treated group) were diagnosed by integrated TCM and western medicine (WM), and treated according to Syndrome Differentiation, the amount of WKF was adjusted according to various .Syndromes. The control group consisted of 54 patients, took Weisu granule without considering their Syndromes. Besides, 15 healthy subjects comprised of the control group. Gastroscopy was conducted both before and after the treatment, mucosal sample was taken from antral region of stomach for pathological changes, for IM classification through histochemical staining and for determination of gastric mucosal Zn, Cu, cAMP, SOD, serum LPO and3 H-TdR lymphocyte conversion test (LCT). Results: (1) The symptomatic and pathologic therapeutic effect of the treated group were markedly better than those of the control group (P< 0. 05, P < 0. 01 ). (2)The levels of gastric mucosal Zn, Cu, cAMP, SOD and 3H-TdR LCT of the treated group before treatment were all lower than that of the healthy control group, but they were markedly increased after treatment, while serum LPO, however, increased before treatment, significant difference existed between the above groups (P< 0.05, P< 0.01 ). Conclusion: WKF can reverse IM and ATP of Spleen Deficiency Syndrome through the mechanism of improving the level of gastric mucosal Zn, Cu, cAMP and SOD, promoting cytodifferentiation, improving cytoimmunity, reducing superoxide and LPO.

关 键 词：胃肿瘤 癌前病变 胃康复冲剂 中医药疗法 

分 类 号：R273[医药卫生—中西医结合]