溶栓治疗急性心肌梗塞对血清超氧化物歧化酶活性的影响  

The effect of intravenous thrombolysis therapy in acute myocadial infartion on serum superoxide dismutase

作　　者：郑刚[1] 刘兆昶[2] 杨顺来[2] 刘继会[2] 陈晴[2] 

机构地区：[1]天津医科大学第一中心医院内科,300011 [2]天津市第三医院

出　　处：《临床内科杂志》2000年第2期93-94,共2页Journal of Clinical Internal Medicine

摘　　要：目的探讨溶栓治疗急性心肌梗塞（ＡＭＩ）对血清超氧化物歧化酶（ＳＯＤ）活性的影响。方法５１例ＡＭＩ患者分成溶栓再通组（３２例）、溶栓未通组（１９例）。结果溶栓再通组，不同时间测定的血浆ＳＯＤ浓度均高于对照组（Ｐ＜０．０１、＜０．０５）。结论只有使梗塞相关血管（ＩＲＡ）再通，才能通过增加心肌细胞内ＳＯＤ活性，对抗氧自由基对心肌细胞的损害作用。Objective The aim of this study was to observe the effect of intravenous thrombolysis therapy in acute myocardial infarction(AMI) on serum superoxide dismutase(SOD). Methods Fifty patients with AMI were divided into intravenous thrombolysis group (n= 32) and non thrombolysis group (n = 19). Results in differenl timepoints the ctivities of serum SOD in reperfusion group were significantly higher than those non throm bolysis group(p<0. 05 P<0. 01 ). Conclusion This study shows that the reperfusion of infarct-related artery (IRA) could protect cardiomycytes from oxygen free-radical induced injury,because of increase in SOD activity in cardomyocytes.

关 键 词：急性 心肌梗塞 溶栓疗法 血清 超氧化物歧化酶 

分 类 号：R542.22[医药卫生—心血管疾病]