鳞癌与脂溢性角化病DNA倍体图像定量分析  

DNA Content Image Quantitative Analysis of Sebaceous Keratosis and Squamous Cell Carcinomas.

作　　者：王晓彦[1] 萨娜 王泽民[1] 夏养志[3] 

机构地区：[1]内蒙古医学院附属医院皮肤科,010050 [2]内蒙古医院皮肤科 [3]内蒙古医学院病理教研室

出　　处：《中国皮肤性病学杂志》2000年第2期88-89,共2页The Chinese Journal of Dermatovenereology

摘　　要：目的　对脂溢性角化病 (SK)及侵袭性癌进行DNA定量分析 ,以回顾性探讨两者之间的关系。方法　应用HI CI真彩色病理图像分析仪对 9例SK、16例鳞癌 (SCC)进行DNA倍体图像分析。结果　SCC多呈现C5、>C5 ,SK多呈现C3 4,但 1例SK组织病理示增生活跃 ,DNA倍体分析出现少量 ( 7.8% )的 >C5细胞 ,与SCC比较差异显著 (P <0 .0 1) ,提示部分染色体已发生了质变 ,有癌变潜在可能。结论　如临床上遇到SK有增大趋势 ,需取材做组织病理及DNA含量分析 ,对预测潜在的癌发生有重要价值。Objective To retrospectively explore the relationships of DNA content between Sebaceous Keratosis(SK)and Squamous Cell Carcinomas(SCC).Methods DNA content of 9 cases SK and 16 cases SCC was determined by HI CI image analysis system.Results SCC DNA content showed C5、>C5,SK showed C3 4.one of 9 cases SK showed hyperplasia in HE staining and there was 7.8%>C5 cells in the DNA content.The difference was significant when compared with that of SCC(P<0.01).Conclusion It suggests when SK growing is observed in clinic,histopathologic examing and DNA content analysis are necessary and this means important value of predicting potential cutaneous carcinomas formation.

关 键 词：脂溢性角化病 DNA倍体 图像定量分析 鳞癌 

分 类 号：R758.73[医药卫生—皮肤病学与性病学] R730.261[医药卫生—临床医学]