非水滴定法测定奈拉滨原料药的含量  

Determination of Nelarabine by Nonaqueous Titration Method

作　　者：黄巧巧[1] 丁俊杰[1] 罗金文[1] 

机构地区：[1]浙江省食品药品检验所,浙江杭州310004

出　　处：《中国药业》2012年第4期34-35,共2页China Pharmaceuticals

摘　　要：目的建立奈拉滨原料药的含量测定方法。方法以0.1 mol/L的高氯酸溶液为滴定液,采用非水滴定法测定,并比较了不同溶剂和不同指标剂对测定结果的影响。结果以冰醋酸为溶剂,照电位滴定法滴定,终点明显,方法可行。连续测定5次,平均含量为99.8%(RSD=0.22%),测得结果与液相色谱法结果基本一致。结论该方法操作简便、精密度高,可作为奈拉滨原料药含量测定的方法。Objective To establish a method for the determination of Nelarabine. Methods Nelarabine assay was performed by nonaqueous titration metod,using 0. 1 mol/L perchloric acid VS as titrant. Effect of different dissolvents and indicators on the titration endpoint was compared in this paper. Results Using acetic acid as solvent and determining the endpoint potentiometrically 5 times, the average content of Nelarabine is 99. 8% （RSD =0.22% ）, the result is consistent with HPLC. Conclusion The method is simplicity and precision,and can be used to determine the content of Nelarabine APIs.

关 键 词：奈拉滨 非水滴定法 高氯酸滴定液 含量测定 

分 类 号：R927.2[医药卫生—药学] R979.12