酚妥拉明联合垂体后叶素治疗老年支气管扩张伴大咯血临床疗效分析  

Analysis of Clinical Efficacy of Phentolamine Combined with Pituitrin for the Treatment of Senile Bronchiectasis with Massive Haemoptysis

作　　者：隋东江[1] 刘莹[1] 李伟生[1] 王蓉美[1] 王肇源[1] 

机构地区：[1]空军总医院干部病房3区,北京100142

出　　处：《医学临床研究》2012年第1期62-63,共2页Journal of Clinical Research

摘　　要：[目的]探讨酚妥拉明联合垂体后叶素治疗老年支气管扩张伴大咯血的临床治疗效果及安全性.[方法]将本院呼吸内科2009年4月至2011年4月收治的60例老年支气管扩张伴大咯血病例,随机分为治疗组和对照组两组,每组各30例,治疗组应用酚妥拉明联合垂体后叶素治疗,对照组仅应用酚妥拉明治疗,对比两组的临床疗效及不良反应.[结果]治疗组30例中显效16例,有效13例,总有效率为96.7%（29/30）;对照组显效13例,有效12例,总有效率为83.3%（25/30）,两组总有效率相比较,治疗组优于对照组,且差异具有显著性（ P ＜0.05）.治疗组与对照组不良反应发生率分别为3.3%、10.0%,两组相比较,治疗组明显低于对照组,且差异具有显著性（χ2=11.427,P ＜0.05）.[结论]酚妥拉明联合垂体后叶素治疗老年支气管扩张伴大咯血,安全、有效,不良反应少,尤其对于合并高血压、冠心病、肺动脉高压等疾病的老年支气管扩张伴大咯血病例更为适宜,值得推广应用.[Objective]To explore the clinical efficacy and safety of phentolamine combined with pituitrin for the treatment of senile bronchiectasis with massive haemoptysis. [Methods] Sixty elderly patients with bronchiec- tasis and massive hemoptysis in respiratory department of our hospital from April 2009 to April 201t were random- ly divide into treatment group and control group with 30 cases in each group. The treatment group was treated by phentolamine combined with pituitrin. The control group was treated only by phentolamine. The clinical efficacy and adverse reactions were compared between two groups. [Results]In treatment group, 30 patients were excel- lence and 13 patients were effective, and the effective rate was 96.7% （29/30）. In control group, 13 patients were excellence and 12 patients were effective, and the total effective rate was 83.3 %（25/30）. The total effective rate of treatment group was better than that of control group, and there was significant difference（ P 〈0.05）. The in- cidence of adverse reactions in treatment group and control group were 3.3% and 10.0% respectively. The inci- dence of adverse reactions in treatment group was lower than that in control group, and there was significant difference（x2 = 11. 427, P 〈0.05）, [Conclusion]Phentolamine combined with pituitrin for the treatment of elderly patients with bronchiectasis and massive haemoptysis has certain efficacy with less adverse reaction, and is an ef- fective and safe method, especially for senile cases of bronchiectasis and massive haemoptysis complicated with hy- pertension, coronary heart disease and pulmonary hypertension. Therefore, it is worthy of clinical promotion.

关 键 词：支气管扩张/并发症 支气管扩张/药物疗法 咯血/药物疗法 酚妥拉明/投药和剂量 垂体激素类 后叶/投药和剂量 

分 类 号：R562.22[医药卫生—呼吸系统]