低剂量X线照射对小鼠脑啡肽和内分泌激素的影响  

Influence of low dose X-irradiation on enkephalin and endocrine hormone in male mice

作　　者：龚守良[1] 刘伟宏[1] 刘树铮[1] 

机构地区：[1]白求恩医科大学放射生物教研室

出　　处：《中国病理生理杂志》1990年第1期1-4,共4页Chinese Journal of Pathophysiology

摘　　要：本文报道C_(57)BL/小鼠75mGy全身X线照射后9小时用SRBC腹腔注射进行免疫。在免疫后不同时间,下丘脑脑啡肽(M-Bhk,L-Enk)含量明显降低,血清睾丸酮(TS)水平一直波动在对照组之上,睾丸cAMP含量与TS变化不一致,血清皮质酮(CS)水平与TS变化相反。这些结果提示,低水平电离辐射可引起神经内分泌功能的改变,使下丘脑脑啡肽神经元释放M-Enk和L-Enk降低,CRF-ACTH-CS轴受抑,而GnRH-LH-TS轴增强。C_(57)BL/G male mice were immunized with SRBC 9 hr after 75 mGy whole body X-irradiation. The hypothalamic M-Enk and L-Enk contents were decreased. Serum TS level kept on fluctuating over the control level. The change of testicular cAMP content was not in the same direction as that of the TS. The change of serum CS level was opposite to that of serum TS, These results suggest that the low dose radiation probably cause the changes of neuroendocrine function, leading to the decrement of hypothalamic EOP contents, the supression of CRF-ACTH-CS axis activity and the enhancement of GnRH-LH-TS axis activity.

关 键 词：X线照射 脑啡肽 内分泌激素 鼠 

分 类 号：Q691.5[生物学—生物物理学]