芪葛口服液制备工艺  

Preparation Technology of Qige Oral Liquid

作　　者：周恩丽[1] 孟文娟[1] 徐连明[1] 尚强[1] 杨璐[1] 萧伟[1] 

机构地区：[1]江苏康缘药业股份有限公司中药制药过程新技术国家重点实验室,江苏连云港222001

出　　处：《中国实验方剂学杂志》2012年第5期4-6,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技部973计划(2010CB735604)

摘　　要：目的:优选芪葛口服液制备工艺参数。方法:采用黄芪甲苷含量为检测指标,通过正交设计及单因素试验考察,优选得到最佳制备工艺。结果:最佳工艺为加5倍量水,提取2次,每次2 h,醇沉体积分数60%,采用聚山梨醇酯-80(吐温-80)进行挥发油增溶。结论:芪葛口服液水提、精制工艺满足生产工艺要求。Objective：To establish preparation technology of Qige oral liquid.Method：With the content of astragaloside iv as evaluatiom index,optimum preparation technology was optimized by orthogonal design test and single factor test.Result：Optimum technology was：extracted 2 times with 8 times the amount of water for 2 h each time,the concentration of ethanol precipitation was 60%,Tween-80 was used for solubilizing volatile oil.Conclusion：Water extracting technology and refining process of Qige oral liquid met production technology requirement.

关 键 词：芪葛口服液 黄芪甲苷 正交试验 增溶 澄清度 

分 类 号：R283.6[医药卫生—中药学]