杞元膏加味对2型糖尿病大鼠糖脂代谢的影响  

Effect of Qiyuan Cream Flavored on Blood Glucose and Blood Lipids in Rats with Type 2 Diabetes

作　　者：吕建东[1] 白素芬[1] 张晓鹏[1] 刘瑞丰[1] 张晶[1] 马燕[1] 喇万英[1] 

机构地区：[1]河北联合大学,河北唐山063000

出　　处：《中国实验方剂学杂志》2012年第5期132-135,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技部国际合作项目(2008DFA31050)

摘　　要：目的:观察杞元膏加味对2型糖尿病大鼠血糖、血脂的影响。方法:Wistar雄性大鼠70只,随机抽取10只作为正常对照组(生理盐水),其余以高糖高脂饲料诱导加链脲佐菌素(STZ)35 mg.kg-1ip建立2型糖尿病模型,7 d后选取成模大鼠50只,按血糖高低分为模型对照组(生理盐水)、药物对照组(盐酸二甲双胍0.5 g.kg-1)、杞元膏加味组(低、中、高剂量组以生药计分别为2.5,5,10 g.kg-1),每组10只。连续ig给药3周后,观察各组大鼠血糖、血脂、血清胰岛素等变化。结果:空腹血糖杞元膏加味低、中、高剂量组由模型组(22.00±1.30)mmol.L-1降为(16.00±1.22),(14.63±1.30),(13.25±1.28)mmol.L-1(P<0.05);血清胰岛素杞元膏加味低、中、高剂量组由模型组(11.86±0.79)μg.L-1升为(16.17±0.99),(18.11±0.75),(19.07±0.77)μg.L-1(P<0.05);杞元膏加味低、中、高剂量组均能降低大鼠甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)(P<0.05),升高高密度脂蛋白胆固醇(HDL-C)(P<0.05)。结论:杞元膏加味对糖尿病大鼠有降低血糖,改善血脂,升高血清胰岛素的作用。Objective：To observe the effect of Qiyuan cream flavored（QYCF） on blood glucose and blood lipids in the diabetic rats with type 2 diabetes.Method： Ten of 70 Wistar male rats were selected as normal group,other rats were used to establish type 2 diabetic model by the injection of streptozotocin（STZ） of 35 mg·kg-1through intraperitoneal with high sugar and high fat for 7 days.Then,the rats were divided into model group treated with normal saline,0.5 g·kg-1metformin hydrochloride group,2.5 g·kg-1 dosage of QYCF,5 g·kg-1 dosage group of QYCF and 10 g·kg-1 dosage group QYCF.After 3 weeks of administration level of blood glucose and lipids was observed.Result： Compared with fasting blood glucose（FBG） level in model group（22.00±1.30）mmol·L-1,FBG level in low,medium and high dose QYCF group was（16.00±1.22）,（14.63±1.30）,（13.25±1.28） mmol·L-1,respectively（P0.05）.Compared with serum insulin level of model group（11.86±0.79） μg·L-1,serum insulin level of QYCF groups was（16.17±0.99）,（18.11±0.75）,（19.07±0.77） μg·L-1,respectively（P0.05）.All the three QYCF groups could reduce the serum total cholesterol,triglyceride concentration and low density lipoprotein（P0.05）,raising high density lipoprotein（P0.05） in rats.Conclusion： QYCF has the effects of reducing blood glucose,improving blood lipids and raising serum insulin.

关 键 词：杞元膏加味 2型糖尿病大鼠 血糖 血脂 血清胰岛素 

分 类 号：R285.5[医药卫生—中药学]