大豆总黄酮对大鼠肾虚型骨质疏松病的药效学研究  

Effects of Soybean Flavone on Osteoporosis in Rats with Deficiency of the Kidney

作　　者：金睿[1] 王诗涵[2] 睢博文[3] 金牮[3] 李海燕[3] 

机构地区：[1]吉林市中心医院,吉林吉林132001 [2]辽宁中医药大学药学院,辽宁大连116600 [3]吉林大学药学院,长春130021

出　　处：《中国实验方剂学杂志》2012年第5期159-163,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：吉林科委重点计划项目(20070912)

摘　　要：目的:观察大豆总黄酮对大鼠骨质疏松的治疗作用。方法:采用12月龄雌性大鼠,切除卵巢60 d以后,以大豆总黄酮250,125,62.5 mg.kg-13个剂量连续灌胃(ig)90 d。测血清碱性磷酸酶(ALP)、钙离子(Ca2+)、磷离子(P3-)、钠离子(Na+)、雌二醇(E2)含量;原子吸收法测定骨Ca2+,P3-,Na+,Mg2+含量;骨扫描法测定胫骨骨密度。结果:以大豆总黄酮250,125 mg.kg-1可以增加骨质疏松大鼠血Ca+2,E2,对血中P3-,Na+离子,ALP含量无明显影响;提高骨Ca2+含量,对骨P3-含量具有一定的升高趋势,对骨Na+,Mg2+无明显影响;增加骨密度和骨小梁面积;减少骨吸收,促进骨形成。结论:大豆总黄酮具有治疗肾虚大鼠骨质疏松作用。Objective：To observe effects of soybean flavone on osteoporosis in rats with deficiency of the kidney.Method： Female rats born 12 monthes were executed orariectomy to establish osteoporosis model.After 60 days,total flavonoids of soybean,with dose of 250,125,62.5 mg·kg-1,was ig given for 90 days.The content of ALP,Ca2＋,P3-,Na＋ estradiol（E2） in serum,the content of Ca2＋,P3-,Na＋,Mg2＋in bones was measured,respectively.The bone density of tibia was messured.Result： The level of Ca2＋,E2 of in serim was increased in total flavonoids 250,125 mg·kg-1 groups,but had no obvious effect on the content of P3-,Na＋,ALP in blood;The content of Ca2＋ in bones was increased,but had no obvious influence on Na＋,Mg2＋ in bones,meanwhile the bone density wa increasedd.Conclusion： Soybean flavone has effects on osteoporosis in rats with deficiency of the kidney

关 键 词：大豆总黄酮 骨质疏松 骨密度 

分 类 号：R285.5[医药卫生—中药学]