中药化学成分肠道菌群代谢的研究进展  

Advances in the Intestinal Bacteria Metabolic of Chemical Compositions from Chinese Medicine

作　　者：肖娟[1] 王莹[1] 王新宏[1] 安叡[1] 

机构地区：[1]上海中医药大学,上海201203

出　　处：《中国实验方剂学杂志》2012年第5期247-251,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：2009年度上海市教育委员会"晨光计划"项目(09CG43);2011年度上海市教育委员会科研创新重点项目(11ZZ110)

摘　　要：介绍肠道代谢研究方法及肠道菌群对中药成分的代谢作用,为开展中药代谢研究提供参考。查阅近年国内外有关中药成分肠菌代谢研究方面的相关文献40篇,并对其进行归纳,分析和总结。结果显示目前对肠菌代谢研究主要有4个方面,且对黄酮类,皂苷类,生物碱类,蒽醌类,单萜类等中药成分的肠菌代谢研究最多。肠道菌群对中药成分的生物转化以水解为主,不少苷类成分肠菌代谢为苷元后更易吸收发挥药效。肠道药物代谢研究对临床中西药物合用上有指导意义。中药化学成分肠菌代谢研究有助于了解药物作用机制及作用物质基础,加快中药现代化研究进程。To review the intestinal tract metabolism research methods and intestinal flora metabolism of Chinese medicine,its gives the reference for the Chinese medicine metabolism research.Literatures in recent years about the intestinal bacteria metabolic of Chinese medicine compositions have been summarized and analyzed.Currently,there are four aspects for intestinal bacteria metabolism research,and more studies on five types of Chinese medicines-flavonoids,saponins,alkaloids,anthraquinones and monoterpenes are developed.Chinese medicines were mainly biotransformated by intestinal micro-flora with hydrolysis,most glycosides were translated into aglycones which were easily be absorbed and utilized.Researches on intestinal drug metabolism have a guiding significance in combined Chinese and Western medicines used in clinical.Intestinal bacterial metabolism of Chinese medicine compositions researches help us to understand the mechanism of drug action,and promote the modernization of traditional Chinese medicine.

关 键 词：肠道菌群 中药化学成分 代谢 药物合用 

分 类 号：R284.1[医药卫生—中药学]