落葵多糖抗肿瘤及对红细胞免疫功能的影响  

The Effects of Basella rubra Polysaccharide on Anti-tumor and Erythrocyte Immune Function

作　　者：李小莉[1] 邹群[1] 张迎庆[1] 孙寅钧[1] 

机构地区：[1]湖北工业大学生物工程学院,湖北武汉430068

出　　处：《时珍国医国药》2012年第1期46-48,共3页Lishizhen Medicine and Materia Medica Research

基　　金：湖北省自然科学基金(No.2006ABA033)

摘　　要：目的研究落葵多糖抗肿瘤及对S180小鼠红细胞免疫功能的影响。方法采用小鼠肉瘤(S180)移植性肿瘤模型,观察分析落葵多糖各组对抑瘤率、胸腺指数、脾脏指数以及红细胞免疫指标的影响。结果落葵多糖对荷瘤小鼠的肿瘤生长均表现出显著的抑制作用,抑瘤率达48.16%;与模型组比较,能明显提高荷瘤小鼠的脾脏指数和胸腺指数,并可增加荷瘤小鼠肿瘤红细胞花环率,提高红细胞C3b受体花环促进率,降低红细胞C3b受体花环抑制率(P<0.0 1)。结论落葵多糖具有一定的抗肿瘤作用,并能明显提高荷瘤小鼠的红细胞免疫功能。其抗肿瘤机制可能与改善荷瘤小鼠红细胞免疫功能有关。Objective To study the anti-tumor effects of the polysaccharide of Basella rubra on erythrocyte immune activity in Sarcomal 180（S180） mice. Methods S180-bearing mice were established and randomly divided into 5 groups：negative control,positive control,three doses of the polysaccharide of Basella rubra（50,100 and 200 mg· kg-1· d-1）.Tumor inhibition rates,values of thymus index,spleen index,rosette rate of erythrocyte adhere to cancer cell（RBC-CaR）,serum rosette forming enhancement rate of erythrocyte C3b（RFER）and serum rosette forming inhibitory rate of erythrocyte C3b receptor（RFIR） were recorded,observed and analyzed. Results The polysaccharide of Basella rubra depressed the growth of tumor-mice remarkably,and its tumor inhibitory rate was 48.16%.Compared with model control group,the spleen indexes and thymus indexes of mice bearing tumor in experiment group were increased.The polysaccharide of Basella rubra increased the content of RBC-CaR and RFER,but decreased the content of RFIR. Conclusion The polysaccharide of Basella rubra exhibits anti-tumor activity.It can improve the erythrocyte immunologic function of tumor-mice,which may be one of anti-tumor mechanisms.

关 键 词：落葵 多糖 抗肿瘤 红细胞免疫 

分 类 号：R962[医药卫生—药理学]