乙吗噻嗪与硫酸氢小檗碱合用的药代动力学及其抗心律失常作用的实验观察  

Experimental Observation of Pharmacodynamics of Moricizine and Berberine Combination and Its Anti-arrhythmic Effects on Rabbits

作　　者：胡萍[1] 张才丽[1] 

机构地区：[1]天津医科大学药理教研室,300070

出　　处：《天津医药》2000年第3期164-166,共3页Tianjin Medical Journal

摘　　要：目的:观察有关药物对实验动物心律的作用。方法:从药效动力学和药代动力学两方面研究小剂量乙吗噻嗪(Mor)和硫酸氢小檗碱(Ber)合用,对抗肾上腺素(EP)所致家兔心律失常的作用。结果:Mor(2.2mg/kg)和Ber(3mg/kg)全量合用及半量合用,可明显推迟心律失常(VA)和室速(VT)的发作,缩短持续时间,并减少两者的发生率。结论:采用高效液相色谱法测定Ber与Mor的血药浓度,药物动力学参数均无显著影响。Purpose:The anti-arrhythmic effects of Moricizine(Mor)with Berberine(Ber)combination in small dose on adrenaline-induced arrhythmias and pharmacokinetics of Mor in conscious rabbits were studied. Methods and Results: The results re-vealed that combination of Mor(2.2 mg/kg)and Ber(3 mg/kg)and half dose combination prominently delayed the onset of VA and VT,reduced the duration of VA,respectively. The incidences of VT and VA reduced. An analytical method was es-tablished for determining serum concentration of Mor with HPLC. Conclusion: It is supposed that Ber has no influence on the metabolism of Mor and pharmacokinetic parameters in rabbits.

关 键 词：心律失常 乙吗噻嗪 硫酸氢小檗碱 药代动力学 

分 类 号：R541.7[医药卫生—心血管疾病] R972.2[医药卫生—内科学]