系统性红斑狼疮患者血清超敏C反应蛋白水平与心血管危险因素的关系  

The Association between High-sensitivity CRP（hs-CRP） and Cardiovascular Risk Factors in Patients with Systemic Lupus Erythematosus

作　　者：周二叶[1] 顾美华[1] 陈志伟[1] 邓迎苏[1] 武剑[1] 

机构地区：[1]苏州大学附属第一医院风湿科,江苏苏州215006

出　　处：《中国血液流变学杂志》2011年第4期640-642,共3页Chinese Journal of Hemorheology

摘　　要：目的在系统性红斑狼疮患者中分析超敏C反应蛋白（hs-CRP）与心血管危险因素的关系。方法收集200例系统性红斑狼疮患者的一般资料，包括：、性别、年龄、病程、身高、体重和血压；检测血清hs-CRP、血清总胆固醇、甘油三酯、C3、C4~ESR；计算体重指数和sLE疾病活动指数（SLEDAI）。结果hs-CRPTk平与sLEDAI及补体c3、c4之间无明显相关（P〉0．05），而与病程、BMI、血压、血清总胆固醇、甘油三酯、CI冲和EsR之间呈正相关（P〈0．05）。结论研究表明：在SLE患者中检测hs．CRP的水平尽管不能作为疾病活动的标志，但能够用于评估其心血管风险。Objective To investigate the association between high-sensitivity CRP（hs-CRP） and cardiovascular risk factors in patients with systemic lupus erythematosus（SLE）.Methods In 200 patients with SLE,the general information including gender, age,disease duration,height,weight, and blood pressure was collected. The levels of hs-CRP, trigalloyl glycerol（TG）,total cholesterol（TC）,C3,C4 and ESR were measured.The body mass index and SLE disease activity index（SLEDAI） were calculated.Results High sensitivity CRP was not associated with SLEDAI,C3,C4（P 〉 0.05）.hs-CRP levels were significantly correlated with disease duration,BMI,blood pressure,TC,TG, CRP and ESR（P 〈 0.05）.Conclusions The results suggest that measurement of hs-CRP, though not valuable as marker of disease activity in SLE may be of some use in the assessment of cardiovascular risk.

关 键 词：超敏C反应蛋白 心血管危险因素 系统性红斑狼疮 

分 类 号：R593.241[医药卫生—内科学]