胃蛋白酶原在胃癌诊断中的价值探讨  

Evaluation of the Value of Serum Pepsinogen in the Diagnosis of Gastric Cancer

作　　者：徐晓文[1] 冯萍[2] 陈芳[2] 茅挺[2] 

机构地区：[1]苏州市广济医院检验科,江苏苏州215008 [2]苏州大学附属第二医院检验科,江苏苏州215004

出　　处：《中国血液流变学杂志》2011年第4期717-719,共3页Chinese Journal of Hemorheology

摘　　要：目的通过测定血清胃蛋白酶原（pepsinogen，PG）PGⅠ、PGⅡ的水平及其比值变化，探索血清PG在胃癌诊断中的应用价值。方法采用ELISA方法，测定胃癌患者（23例）、胃良性病变患者（69例）和健康对照人群（25名）的血清PGⅠ、PGⅡ的水平。结果胃癌患者组血清PGⅠ水平及PGⅠ／PGⅡ比值低于胃良性病变组及健康对照组，差异有统计学意义（户〈0．05）；胃癌患者组PGII水平与健康对照组及胃良性病变组比较，差异无统计学义（P〉0．05）；Logistic回归分析显示：PGⅠ对胃癌分类能力为80．6％，PGⅠ／PGⅡ比值对胃癌分类能力为73．9％；ROC曲线显示：PGⅠ、PGⅠ／PGⅡ比值的曲线下面积（AUC）分别为0．82、0．77。结论血清PGⅠ的含量及PGⅠ／PGⅡ的比值改变，可以作为胃癌诊断的重要指标。Objective To evaluate value of the levels of gastric cancer by detecting serum levels of pepsinogen of PG Ⅰ ,PG Ⅱ ,and PG Ⅰ/PG Ⅱ ratio in the diagnosis Ⅰ （PG Ⅰ ） and pepsinogenⅠ/（PG Ⅱ ） in gastric cancer patients. Methods The serum levels ofPG Ⅰ ,PG Ⅱ of the normal control group（n=25）,gastric cancer group（n=23） and the benign group（n=69） were detected by ELISA. Results The serum PG Ⅰ ,PG Ⅰ/PG Ⅱ levels of gastric cancer group were lower than the normal control group and the benign group（P 〈 0.05）;The PG II levels of gastric cancer group were not significantly different from the benign group and the normal control group（P 〉 0.05）;The logistic regression showed that the classification abilities of PG I and PG Ⅰ/PG Ⅱ to gastric cancer were 80.6% and 73.9% respectively.The ROC curve showed that the AUC（area under curve） of PG I and PG Ⅰ/PG Ⅱ were 0.82 and 0.77 respectively.Conclusion The changes of serum levels of PGⅠ and PG Ⅰ/PG Ⅱ ratio are important indexes in the diagnosis of gastric cancer.

关 键 词：胃蛋白酶原 胃癌 ELISA 

分 类 号：R446.11[医药卫生—诊断学]