GC法测定棕榈哌泊噻嗪中残留溶剂二甲基亚砜  

Determination of Residual Solvent Dimethyl Sulfoxide in Pipotiazine Palmitate by Gas Chromatography

作　　者：何晓艳[1] 潘震宇[1] 肖菁[1] 

机构地区：[1]湖南省药品检验所,长沙410001

出　　处：《中国药师》2011年第12期1725-1726,共2页China Pharmacist

基　　金：国家药品标准提高研究课题(药典化发[2010]84号文;编号:附件3-903)

摘　　要：目的:建立气相色谱(GC)法测定棕榈哌泊噻嗪中二甲基亚砜(DMSO)有机溶剂残留量。方法:采用PC-624毛细管柱(60 m×0.32 mm,1.80μm),FID检测器,检测器温度为230℃,进样口温度为210℃,乙醇为溶剂。结果:二甲基亚砜与溶剂峰完全分离,DMSO在1.22～978.4μg·ml^(-1)浓度范围内线性关系良好(r=0.999 8),平均回收率为99.5%。结论:该方法可用于棕榈哌泊噻嗪中二甲基亚砜残留量测定。Objective ： To establish a gas chromatography method for the determination of residual solvent dimethyl sulfoxide in pipofiazine palmitate. Method： A PC-624 capillary column （60 m ×0. 32 mm, 1.80 μm） and hydrogen flame ionization detector （FID） were applied in the study. The detector temperature was 230℃ and the sample-input temperature was 210 ℃ with ethanol as the solvent. Result： The established method could separate dimethyl sulfoxide （DMSO） and the solvent completely, and DMSO had a good linearity within the range of 1.22-978.40 μg·ml-1 （r = 0. 999 8）. The average recovery was 99. 5%. Conclusion： It is practicable to apply the method in the determination of dimethyl sulfoxide in pipotiazine palmitate.

关 键 词：气相色谱 棕榈哌泊噻嗪 二甲基亚砜 

分 类 号：R917[医药卫生—药物分析学]