氟的遗传毒性研究  

Study on the geuotoridty of fluoride

作　　者：马凤[1] 吴云鹏[1] 梁超轲[1] Y.Li G.K.Stookey B.P.Katz E.J.Brizendine 

机构地区：[1]中国预防医学科学院环境卫生与卫生工程研究所,北京100050 [2]美国印第安纳大学,in46202

出　　处：《医学研究通讯》2000年第3期4-6,共3页Bulletin of Medical Research

基　　金：美国 NIH/NID PHS/POI DE-09835研究基金

摘　　要：本文报道燃煤污染高氟与饮水高氟暴露人群外周血淋巴细胞姊妹染色单体交换(SCE)频率。不同燃煤氟暴露人群4个组和不同饮水氟暴露人群6个组,年龄4O～60岁,每组120人。该结果经统计学分析,高、低氟接触不同人群组之间SCE频率没有差异,即未发现氟的遗传毒性。The investigation was to determine on the genotoxicity of fluoride by fanner's long - term exposure in coal burning fluorosis as well as drinking water fluorosis epidemic areas. The sister chromatid exchange (SCE) frequency in blood lymphocytes from these subjects who were 40 ~ 60 years old. 4 coal burning group and 6 drinking water groups, each groupl20individuals were analyzed. The results demonstrated that different fluoride level exposure in indoor air and drinking water does not increase SCE frequency, and conclude that fluoride have no genotoxic effects in humans.

关 键 词：氟 遗传毒性 氟中毒 SCE 

分 类 号：R995[医药卫生—毒理学] R599.9[医药卫生—药学]