重组人促红素联合米多君对终末期心力衰竭患者心功能及血流动力学的影响  

Effect of association of erythropoietin and midodrine on the cardiac function and hemodynamics in patients with end-stage heart failure

作　　者：吴钰燕 程颖 解强 林桂雄 冯燕玲 李劲草 卓裕丰 张鹏 黄冰生 

机构地区：[1]广州番禺何贤纪念医院心内科,511400

出　　处：《新医学》2011年第12期805-807,共3页Journal of New Medicine

基　　金：广州市番禺区科技局科技计划项目(2011-Z-03-39)

摘　　要：目的:探讨重组人促红素(EPO)联合米多君对终末期心力衰竭患者心功能及血流动力学的影响。方法:将43例终末期心力衰竭患者随机分为联合治疗组(n=22)与对照组(n=21),两组均接受规范的慢性充血性心力衰竭药物治疗,联合治疗组在此治疗基础上再给予EPO(4 000 IU/次,皮下注射,每周2次)、多糖铁复合物胶囊(150 mg,每日3次)及米多君(2.5mg,每日2次)。随访3个月,分别于治疗前及随访期结束时行血压、血常规、脑钠肽、心脏彩色多普勒超声及平均肺动脉压(mPAP)检查,并记录两组患者心血管事件发生率。结果:随访结束时,与对照组比较,联合治疗组血浆血红蛋白、收缩压、舒张压明显升高,血浆脑钠肽水平及因心力衰竭再次住院率明显降低,两组比较差异有统计学意义(P<0.05);两组的mPAP及LVEF比较差异无统计学意义(P﹥0.05)。结论:在慢性充血性心力衰竭规范治疗基础上,终末期心力衰竭患者加用EPO及米多君可改善心功能及血流动力学。Objective：To investigate the effect of association of Erythropoietin and Midodrine on the cardiac function and hemodynamics in patients with end-stage heart failure.Methods： Forty-three patients with end-stage heart failure were recruited into this study.Patients were randomly divided into two groups,combination treatment group（n=22） and control group（n=21）.All patients in the two groups were treated with a standard anti-heart failure therapy and only patients in combination treatment group were administrated erythropoietin,iron and Midodrine.All subjects were followed up for 3 months.The levels of blood pressure,hemoglobin,BNP,LVEF and mean pulmonary artery pressure（mPAP） were examined at the beginning and the end of the study.The rates of cardiovascular events in the two groups were recorded.Results：The levels of blood pressure and hemoglobin were significantly increased and the levels of BNP and the rates of rehospitalization was significantly decreased in the combination treatment group（P﹤0.05）.There was no significant difference in LVEF and mPAP between the two groups.Conclusion：On the basis of standard therapy,combination of erythropoietin and midodrine treatment may improve the cardiac function and hemodynamics in patients with end-stage heart failure.

关 键 词：心力衰竭 重组人促红素 米多君 心功能 血流动力学 

分 类 号：R541.6[医药卫生—心血管疾病]