氟砷联合染毒后大鼠子代心肌组织的电镜观察  

Observation on Offsprings’ Cardiac Muscle of Parents Rats Exposed to Fluoride and Arsenic Under Electron Microscope

作　　者：胡汉华[1] 谢瑶芸[1] 汤建安[1] 谢凤莲[1] 王新英 张晨[2] 姚华[2] 

机构地区：[1]新疆医科大学电镜室 [2]新疆医科大学公共卫生学院,新疆乌鲁木齐830054

出　　处：《地方病通报》2000年第1期13-14,共2页Endemic Diseases Bulletin

基　　金：国家自然科学基金! (39560 0 75)

摘　　要：为探讨氟砷联合作用对大鼠子代心血管系统的影响 ,采用两代一窝繁殖实验的方法 ,对亲代接触不同剂量氟砷后其子代心肌组织进行电镜观察。结果显示各染毒组大鼠子代心肌组织超微结构均有一定的改变 ,可见肌丝溶解、线粒体肿胀及空泡变性 ,肌浆网扩张 ,闰盘连接处间隙增宽等 ,认为氟砷联合作用对大鼠子代心肌组织有一定的影响。In order to explore the effects of fluoride and arsenic on the offsprings' cardiovalar system of the exposed rats, with a two generation reproductive test, the changes of cardiac muscle rat offsprings, whose pa rents exposed to the different doses of fluoride and arsenic, were observed under electron microscope. The pathological changes appeared in some organellae of cardiac muscle of rats' offsprings' in all exposed groups, such as myolysis,mitochondriom swelling,sarcoplasmic reticulum and interculated disc expending et al, it suggested that fluoride and arsenic affect the offspring cardiovalar system of rats.

关 键 词：氟砷联合染毒 子代 超微结构 心肌组织 

分 类 号：R995[医药卫生—毒理学] R－332[医药卫生—药学]