猪胰腺十二指肠移植后急性排斥反应的病理变化特点  

Histopathologic characteristics of acute rejection following porcine pancreaticoduodenal allograft.

作　　者：李为苏[1] 罗开[1] 李宁[1] 石群立[2] 黎介寿[1] 

机构地区：[1]南京军区南京总医院普通外科研究所,210002 [2]南京军区南京总医院病理科,210002

出　　处：《中华器官移植杂志》2000年第2期103-105,共3页Chinese Journal of Organ Transplantation

基　　金：全军"九五"重点课题基金!96Z0 0 2

摘　　要：目的　研究猪胰腺十二指肠移植术后胰腺和十二指肠粘膜急性排斥反应的病理变化特点及它们之间的关系。方法　 12头猪作同种异体胰腺十二指肠移植 ,平均分为未用药组和治疗组 ,术后定期取胰腺和十二指肠粘膜作普通病理检查。结果　胰腺急性排斥反应时首先并持续损伤腺泡 ,以后累及胰腺导管 ,最后为胰岛和血管。胰腺和十二指肠粘膜急性排斥反应大多同时存在 ;间质性排斥反应评分相同者占 73% ,评分不同者中 ,胰腺评分较高 ,占 5 8.3%。结论　胰腺十二指肠移植后急性排斥反应最先累及胰腺外分泌系统 ;最终累及内分泌组织。十二指肠粘膜活检有助于确定有无胰腺急性排斥反应 ,但不能确定其严重程度。Objective To investigate the histopathologic characteristics of acute rejection following porcine pancreaticoduodenal allografts and to assess the pathologic changes correlation between pancreas and duodenum.Methods 12 pigs were subjected to pancereaticoduodenal allogrfts and equally divided into two groups:untreated group and treated group (receiving triple therapy for 7 days). Serial biopsies were performed in pancreaticoduodenal allografts.Results Acinar lesions existed early and constantly during rejection followed by duct lesion, finally vascular and islet lesions. Acute interstitial rejection in the duodenum was correlated with that in the pancreatic graft. Concordance of duodenal and pancreas histological change occurred in 73%. Discordant cases showed 58.3% pancreas with higher grades of interstitial rejection.Conclusions Exocrine tissue was damaged in the early stage of pancreatic rejection and islets were affected in the late stage. The diagnosis of pancreatic rejection can be established by the results of duodenal biopsy. The severity of the rejection can not be confirmed by duodenal biopsy.

关 键 词：胰十二指肠移植 病理学 急性排斥反应 实验研究 

分 类 号：R392.4[医药卫生—免疫学]