血清内脂素与急性冠状动脉综合征的相关性  

Study on the relationship between serum visfatin levels and acute coronary syndrome

作　　者：华启洋 张宁汝[2] 周桂建[2] 张恒[2] 

机构地区：[1]江苏省昆山市第四人民医院内科,215300 [2]蚌埠医学院第一附属医院心血管科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2011年第12期1341-1342,1345,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨血清内脂素与急性冠状动脉综合征(ACS)的关系及其在斑块失稳定性中的作用。方法:采用ELISA方法分别检测40例ACS(ACS组)、22例稳定型心绞痛(SAP组)和26例非冠心病患者(对照组)的血清内脂素及基质金属蛋白酶-9(MMP-9)水平,并比较两者相关性。结果:ACS组血清内脂素和MMP-9水平均显著高于SAP组和对照组(P<0.01)。ACS患者中血清内脂素与MMP-9呈显著正相关关系(P<0.01)。结论:血清内脂素与ACS具有相关性,可作为预测斑块稳定性的标志物,对其测定有助于ACS的早期防治。Objective：To study the relationship of serum visfatin levels and acute coronary syndrome（ACS） and the role of serum visfatin in vulnerable plaques.Methods：The serum levels of visfatin and matrix metalloproteinase-9（MMP-9） in 40 cases with ACS,22 cases with stable angina pectoris（SAP） and 26 control cases were measured by ELISA,and the correlation between visfatin and MMP-9 was evaluated.Results：The levels of visfatin and MMP-9 in cases with ACS were significantly higher than those in SAP and control groups（P0.01）.Significant positive correlation of visfatin and MMP-9 in patients with ACS were found（P0.01）.Conclusions：The serum levels of visfatin and ACS exist correlation.Visfatin may act as the biomarkers of vulnerable plaques and be applied in the early prevention and management of ACS.

关 键 词：冠状动脉疾病 急性冠状动脉综合征 内脂素 基质金属蛋白酶-9 易损斑块 

分 类 号：R543.3[医药卫生—心血管疾病]