吸入对苯二甲酸粉尘大鼠肺表面活性物质的改变  

Changes of pulmonary surfactant in the rat lung exposed to terephthalic acid

作　　者：施爱民 王顶贤 王心如[2] 徐锡坤[2] 徐峰 龚楠[2] 何冬宁[2] 姚宏伟 

机构地区：[1]仪征化纤集团公司预防保健中心,仪征211900 [2]南京医科大学公共卫生学院

出　　处：《卫生研究》2000年第2期71-72,共2页Journal of Hygiene Research

基　　金：国家卫生部自然科学基金! ( No.3 -92 -10 9);江苏省科委自然科学基金 !( No.BS92 0 3 3 )

摘　　要：用高效液相色谱法检测了动式吸入对苯二甲酸粉尘后大鼠支气管肺泡灌洗液中肺表面活性物质磷脂的含量,各实验组染尘几何平均浓度分别为8.93、274.45和618.12mg/m3。结果显示中、高剂量实验组磷脂酰胆碱、磷脂酰甘油、磷脂酰肌醇均较对照组减少(P<0.001),提示吸入对苯二甲酸粉尘可影响肺泡型上皮细胞肺表面活性物质的合成与分泌功能。The contents of phospholipids in the lung surfactant in bronchoalveolar lavage fluid(BALF) of rats inhaled terephthalic acid (TPA) dust were analysed with high pressure liquid chromatography (HPLC).The average geometric concentrations of TPA dust in experimental groups were 8 93,274 45 and 618 12mg/m 3 respectively.The results showed that phosphatidylcholine(PC),phosphatidyl glycerol(PG),and phosphatidylinositol(PI) of the rats exposed to TPA at the middle and high concentrations were decreased as compared with those in the control ( P <0 001).It was suggested that the functions of producing and secreting pulmonary surfactant in type Ⅱ epithelial cells were damaged after inhalating TPA dust.

关 键 词：对苯二甲酸 肺表面活性物质 高效液相色谱 粉尘 

分 类 号：R135.2[医药卫生—劳动卫生] R134[医药卫生—公共卫生与预防医学]