锌金属硫蛋白拮抗甲基汞对红细胞膜损伤的作用  

The protective effects of zinc metallothionein against erythrocyte membrane damage induced by methylmercury

作　　者：徐乐焱[1] 王毅[2] 邱炳源[2] 王振 

机构地区：[1]中国医学科学院 [2]白求恩医科大学预防医学院 [3]秦皇岛市卫生防疫站

出　　处：《卫生研究》2000年第2期80-82,共3页Journal of Hygiene Research

摘　　要：为了探讨锌金属硫蛋白(ZnMT)拮抗MeHg对细胞膜的损伤作用及其机理,为预防甲基汞(MeHg)中毒提供科学依据,研究了不同剂量的锌诱导产生的ZnMT对MeHg染毒小鼠红细胞膜构象、膜巯基含量、膜流动性和膜通透性等的影响,实验结果表明:不同剂量的Zn可以诱导小鼠肝脏产生ZnMT,随着实验组Zn剂量的增加,肝脏内ZnMT的含量也相应的增加,呈剂量-效应关系(r=0.996)。ZnMT具有保护膜构象及膜巯基、拮抗MeHg对膜流动性及膜通透性的损伤作用。实验结果同时显示了诱导ZnMT的锌的剂量要适当,过高则有毒性作用。The influences of zinc metallothionein(ZnMT) induced by Zn on mice erythrocyte membrane configuration, membrane sulfhydryl content, membrane fluidity, membrane permeability and so on after methylmercury (MeHg) treatment were studied, the protection of ZnMT against the membrane damage of MeHg was studied. The results showed that Zn could induce the production of ZnMT in the liver of mice. With the increase of Zn content, the level of ZnMT increased and had dose effect relationship between them(r=0 996). ZnMT could protect membrane configuration and SH and prevent the damage of MeHg on the membrane fluidity and permeability. The results also showed that the dose of Zn administered to mice should be appropriate. High doses of Zn could cause damages.

关 键 词：甲基汞 锌金属硫蛋白 膜通透性 红细胞膜损伤 

分 类 号：R995[医药卫生—毒理学] R979.3[医药卫生—药学]