甘草黄酮对2型糖尿病大鼠抗氧化能力的影响  

Effect of licorice flavonoids on antioxidative capability in type 2 diabetic rats

作　　者：赵海燕[1] 杨少娟[1] 马永平[1] 刘旺[1] 

机构地区：[1]北方民族大学生物科学与工程学院,宁夏银川750021

出　　处：《中国现代医学杂志》2011年第35期4359-4362,共4页China Journal of Modern Medicine

基　　金：国家自然科学基金(No:30960510);宁夏高等学校科研项目(No:2009JY003);国家民委生态系统模型及应用重点实验室科研项目(No:2008SY06)

摘　　要：目的研究甘草黄酮(LF)对2型糖尿病大鼠抗氧化能力的影响。方法采用高脂高糖饲料喂养结合一次性小剂量腹腔注射链脲佐菌素(STZ)的方法复制T2DM大鼠模型。正常对照组(Control)和模型组(DM)以溶剂(1,2-丙二醇)灌胃,正常给药组(CLF)和甘草黄酮治疗组(LF)以甘草黄酮300 mg/(kg.d)灌胃。6周后,检测实验大鼠的空腹血糖(FBG),测定血清中总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-PX)活性及丙二醛(MDA)含量。结果与DM组相比,LF组大鼠的FBG水平显著降低(P<0.01),血清T-AOC水平显著增高(P<0.01),GSH-PX和SOD抗氧化酶活性显著升高(P<0.01,P<0.05),而血清中MDA含量显著降低(P<0.05)。结论 LF可显著提高2型糖尿病大鼠的抗氧化能力。[ Objective ] To study the effect of licorice flavonoids （LF） on antioxidafive ability in type 2 diabetic rats. [Methods] The type 2 diabetic rat model was replicated by high-fat and high-sugar diet combined with low-dose streptozotocin （STZ） injection. Rats in control and model groups were administered with solvent （1.2-propanediol）. Meanwhile, rats in control treatfaent group （CLF） and licorice flavonoids treatment group （LF） were administered with 300 mg/（kg＇d） of LF. After 6 weeks, the levels of the FBG, T- AOC, SOD, GSH-PX and MDA in serum were examined. [Results] FBG in LF group was significantly lower than those in DM group （P〈0.01）. Comparing with DM group, GSH-PX and SOD activities and T-AOC level in serum were much higher （P〈0.01 or P〈0.05 P〈0.05）; MDA level in serum in LF group was much lower （P〈0.05）. [Conclusion] LF has the significant effect improving antioxidant ability in the type 2 diabetic rats.

关 键 词：甘草黄酮 2型糖尿病 总抗氧化能力 超氧物歧化酶 谷胱甘肽过氧化物酶 丙二醛 

分 类 号：R587.1[医药卫生—内分泌] R-332[医药卫生—内科学]