养生保健1号对脂多糖致小鼠肝损伤的影响  

Effect of Yangshengbaojian Decoction on LPS induced Liver Injury of Mice

作　　者：钱妍[1] 吴整军[1] 陈利平[1] 仝战旗[1] 段冬梅[1] 臧倩[1] 

机构地区：[1]解放军总医院南楼临床中医针灸科,北京100853

出　　处：《中华中医药学刊》2012年第2期276-277,I0005,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家科技支撑计划资助项目(2009BAI86B04)

摘　　要：目的:观察养生保健1号对脂多糖(LPS)诱导小鼠急性肝损伤的保护作用及其对小鼠细胞因子的影响。方法:腹腔注射LPS建立小鼠急性肝损伤模型,养生保健1号灌胃,观察肝脏组织形态变化及小鼠血浆中炎症细胞因子TNF-α和IL-6水平。结果:养生保健1号可明显改善LPS引起的小鼠肝组织病理损伤,降低LPS致小鼠血浆TNF-α和IL-6的升高水平(P<0.05)。结论:养生保健1号对LPS致小鼠肝细胞损伤具有保护作用的作用,可能的机制与减少炎性细胞因子释放有关。Objective ： To observe the effect on LPS induced liver injury and changes of TNF - α and IL - 6 of mice by Yangshengbaojian Decoction（ YS1 ）. Methods ： To establish hepatic injury models by LPS injection, YS1 was given by intragastric administration, the changes of TNF -α and IL - 6 of plasma and histopathology of liver were observed. Results ： YS1 can improve liver pathological injury and reduce the levels of TNF - α and IL - 6. Conclusion ： YS1 can protect LPS induced liver injury in mice and the possible mechanism are related to cyctokines production.

关 键 词：肝损伤 细胞因子 养生保健1号 小鼠 

分 类 号：R285.5[医药卫生—中药学]