甲状腺髓样癌遗传学研究进展  

Genetic Research Advances of Medullary Thyroid Carcinoma

作　　者：徐洪波[1] 虢毅[2] 邓昊[1] 

机构地区：[1]中南大学湘雅三医院医学实验中心,中国湖南长沙410013 [2]中南大学湘雅医学院生理系,中国湖南长沙410078

出　　处：《生命科学研究》2012年第1期74-78,84,共6页Life Science Research

基　　金：国家自然科学基金资助项目(81101339);教育部新世纪优秀人才支持计划项目(NCET-080563);教育部高等学校博士学科点专项科研基金课题(20110162110026);中南大学"升华学者计划"特聘教授岗位项目(邓昊);中南大学湘雅三医院重点培育学科基金项目(临床检验诊断学);中央高校基础研究基金项目(2011JQ014);2011年大学生创新训练立项资助项目(CL11280;DL11446;DL11447)

摘　　要：甲状腺髓样癌(medullary thyroid carcinoma,MTC)是起源于甲状腺C细胞或滤泡旁细胞的恶性肿瘤,分遗传型髓样癌和散发型髓样癌两种.MTC主要由RET原癌基因突变引起,对患者进行基因测序分析能在基因水平诊断MTC,从而为患者早期行预防性手术治疗提供依据.从甲状腺髓样癌临床分型、分子遗传基础及动物模型不同层面进行综述,有利于进一步了解疾病致病机制和开展药物实验性治疗研究.Medullary thyroid carcinoma （MTC） is a malignancy that originates from parafollicular C cells of the thyroid gland, which is divided into two types, including hereditary and sporadic forms. MTC is mainly caused by germline mutations in the RET proto-oncogene. The direct gene sequencing analysis for patients can diagnose MTC at gene level, thereby providing the basis for early preventive surgery treatment. Different angles including the clinical types, basic of molecular genetics and animal models of medullary thyroid car- cinoma are reviewed, which will contribute to further understanding the pathogenic mechanism and would help to carry out drug experimental treatments of this disease.

关 键 词：甲状腺髓样癌 RET原癌基因 遗传 动物模型 

分 类 号：Q754[生物学—分子生物学]