替比夫定对慢性乙型肝炎患者肌酸激酶升高的多因素分析  

Multivariate factors analysis of creatine kinase elevation with telbivudine treatment

作　　者：江远[1] 张玲[1] 吴国庆[1] 杨继源[1] 

机构地区：[1]广州医学院附属深圳沙井医院中医肝病科,广东深圳518104

出　　处：《中西医结合肝病杂志》2012年第1期19-20,40,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：深圳市宝安区科技计划项目资助(No.20110483)

摘　　要：目的:探讨替比夫定对慢性乙型肝炎(CHB)患者肌酸激酶(CK)升高的影响因素。方法:对2010年1月至2011年6月我院使用替比夫定抗病毒治疗的60例CHB患者进行回顾性分析,记录患者年龄、性别、他汀类药物使用史、运动史、肝硬化病史、联合抗病毒治疗史,以及CK、天门冬氨酸转氨酶(AST)等5项实验室检测指标。采用Logistic逐步回归和多元线性回归分析。结果:Logistic回归显示男性、运动等是替比夫定治疗时影响CK水平升高的独立危险因素。多元线性回归显示CK的变化与AST、乳酸脱氢酶(LDH)有线性回归关系,且AST对CK的影响最大。结论:运动是替比夫定治疗时血清CK水平升高的危险因素。因此,建议在替比夫定抗病毒治疗时尽量避免运动疲劳,以防止CK水平升高甚至肌病的发生。Objective：To investigate the factors influencing creatine kinase（CK）elevation of CHB patients with telbivudine treatment.Methods： Clinical data of 60 CHB patients with telbivudine treatment admitted to our hospital from January 2010 to June 2011 were analyzed retrospectively.Indicators such as age,sex,history of using statins,history of sports,liver cirrhosis and combined treatment and 5 laboratory data such as CK and aspartate transaminase（AST）were recorded.Logistic regression and multiple linear regression were introduced for analysis.Results：Male and sport were risk factors of creatine kinase elevation with telbivudine treatment.There was linear regression relationship between the changes of CK and AST or lactate dehydrogenase（LDH）,which AST had the most effect on CK.Conclusion：Sport is risk factor of CK elevation with telbivudine treatment.It suggests that patients should avoid sport fatigue when treated with telbivudine to prevent occurrence of CK elevation and myopathy.

关 键 词：替比夫定/副作用 肌酸激酶升高 回归分析 

分 类 号：R512.62[医药卫生—内科学]