小剂量普通肝素治疗重度慢性乙型病毒性肝炎临床研究  

Clinical analysis of low-dose unfractionated heparin in the treatment of serious chronic hepatitis B

作　　者：朱新功[1] 何小敏[1] 何小峰[1] 张会爱[1] 黄兵[1] 孙红娟[1] 辛建兰[1] 

机构地区：[1]泰兴市人民医院感染科,江苏泰兴225400

出　　处：《海南医学》2012年第6期6-7,共2页Hainan Medical Journal

基　　金：江苏省泰州市科技发展计划项目(编号:2010-102)

摘　　要：目的研究小剂量普通肝素治疗重度慢性乙型肝炎的疗效和安全性。方法将70例重度慢性乙型肝炎患者分为三组,对照组25例予常规护肝退黄抗病毒治疗(甘利欣、苦黄、水溶性维生素、拉米夫定等);腺苷蛋氨酸组20例在对照组治疗基础上,加用腺苷蛋氨酸1000mg加入0.9%生理盐水250ml中静脉滴注,1次/d,10d为一个疗程;肝素组25例在对照组治疗基础上,加用普通肝素钠25mg加入0.9%生理盐水250ml中静脉滴注,1次/d,10d为一个疗程;观察治疗前后患者的血清谷丙转氨酶、胆红素、凝血酶原时间的变化。结果肝素组在重度慢性乙型肝炎的血清谷丙转氨酶、胆红素、凝血酶原时间恢复方面,明显优于对照组(P<0.05),与腺苷蛋氨酸组疗效相近,但肝素组所用费用较腺苷蛋氨酸组低。结论小剂量普通肝素对重度慢性乙型肝炎有明显疗效,且费用低,临床应用安全。Objective To evaluate the clinical efficacy and safety of low-dose heparin in the treatment of patients with serious chronic hepatitis B. Methods Seventy patients with serious chronic hepatitis B were randomly divided into three groups, the control group （n=25） received conventional therapy （diammonium glycyrrhizinate, kuhuan, water-soluble vitamins, lamivudine, etc.）. S-adenosylmethionine group （n=20） were administrated with S-adenosylmethionine 1 000 mg in 250 ml 0.9% saline intravenously based on the conventional therapy, one time per day, 10 days for a course. Heparin gtoup （n=25） were administrated with 25 mg heparin in 250 ml 0.9% saline intravenously, one time per day, 10 days for a course. Serum alanine aminotransferase, bilirubin, prothrombin time were tested before and after treatment. Results The recovery of serum alanine aminotransferase, bilirubin, and prothrombin time in heparin group was significantly better than that in the control group （P〈0.05）, but similar with that in S-adenosylmethionine group, except that the cost ofheparin group was lower. Conclusion Low dose heparin is significantly effective in the treatment of severe chronic hepatitis B, with low cost and safe clinical application.

关 键 词：普通肝素 腺苷蛋氨酸 重度慢性乙型病毒性肝炎 治疗 

分 类 号：R512.62[医药卫生—内科学]