123株铜绿假单胞菌感染分布及耐药性分析  

Analysis on infection distribution and the drug resistance of Pseudomonas aeruginosa

作　　者：李静[1] 蔡木发[1] 崔国辉[1] 

机构地区：[1]广东医学院附属医院检验科,广东湛江524001

出　　处：《海南医学》2012年第6期101-103,共3页Hainan Medical Journal

摘　　要：目的了解铜绿假单胞菌的感染分布及耐药现状，为临床治疗感染提供依据。方法采用VITEK系统进行细菌鉴定及药敏检测，应用WHONET软件进行耐药统计分析。结果铜绿假单胞菌最常见分离自痰标本（69．1％），其次是伤口分泌物（14．6％）。对铜绿假单胞菌耐药率较低的的药物依次为哌拉西林／他唑巴坦（24．4％）、亚胺培南（27．6％）、阿米卡星（39．0％）、头孢他啶（40．7％）、氨曲南（46．7％），铜绿假单胞菌对头孢曲松、头孢吡肟、哌拉西林、替卡西林／克拉维酸、庆大霉素、妥布霉素、环丙沙星和左氧氟沙星的耐药较严重，耐药率在52．8％-92．7％之间。结论铜绿假单胞菌耐药性较严重，合理用药及加强细菌耐药性监测十分必要。Objective To investigate the distribution and resistance of Pseudomonas aeruginosa, and to provide guidance for clinical treatment. Methods Pseudomonas aeruginosa was identified and its antimicrobial sensitivity test was determined by VITEK system. The antimicrobial ressistance rates were analyzed by WHONET software. Results Pseudomonas aeruginosa was the most detected in phlegm specimen （69.1%）, followed by purulence （14.6%）. Pseudomonas aeruginosa showed low resistance to Piperacillin/tazobactam （24.4%）, imipenem （27.6%）, amikacin （39.0%）, ceftazidime （40.7%） and aztreonam （46.7%）, and high resistance to ceftriaxone, cefepime, piperacillin, ticarcillin/clavulanic acid, gentamicin, tobramycin, ciprofloxacin and levofloxacin, with a resistance rate of 52.8%- 92.7%. Conclusion The resistance ofPseudomonas aeruginosa is high. It is of great importance to use drugs rationally and enhance the monitoring of drug resistance.

关 键 词：铜绿假单胞菌 抗菌药物 耐药性 

分 类 号：R378.991[医药卫生—病原生物学]