复发性非霍奇金淋巴瘤应用IEBP治疗35例疗效观察  

Recurrent non-Hodgkin′s lymphoma application IEBP treatment of 35 patients

作　　者：唐文 罗勇忠[2] 

机构地区：[1]湖南省祁阳县人民医院,湖南祁阳426100 [2]湖南省肿瘤医院,湖南长沙410000

出　　处：《中国当代医药》2011年第34期23-24,共2页China Modern Medicine

摘　　要：目的:评价由异环磷酸胺、鬼臼乙叉甙、平阳霉素、泼尼松组成的IEBP方案治疗复发或难治性非霍奇金淋巴瘤(NHL)的疗效及安全性。方法:选取本院2007年1月～2010年1月收治的35例复发或难治性非霍奇金淋巴瘤接受新方案即IEBP方案化疗,具体为异环磷酸胺每天1.5g/m2,鬼臼乙叉甙100mg/d,连用3d;平阳霉素20mg/m2于第1天给予,泼尼松30mg/d,口服,于1～14d给予。治疗周期为21d。完成4周期以上者作疗效评价并观察毒副作用。结果:35例患者中,完全缓解(CR)14例,部分缓解(PR)9例,总有效率为65.7%,主要毒副作用为白细胞减少、骨髓抑制、脱发、胃肠道反应等,患者均能够耐受。结论:IEBP是治疗复发或难治性非霍奇金淋巴瘤安全、有效的解救方案之一,值得进一步推广。Objective： To evaluate the efficacy and safety of the different cyclic amines, etoposide, bleomycin, prednisone regimen consisting of IEBP relapsed or refractory non-Hodgkin＇s lymphoma （NHL）. Methods： Chose the 35 cases patients in our hospital from January 2007 to January 2010 were treated of relapsed or refractory non-Hodgkin＇s lymphoma receiving the new program IEBP chemotherapy. In particular, different cyclic amines day 1.5 g/m2, ghost mortar etoposide 100 mg/day, act 3 days; Bleomycin 20mg/m2 given in 1 day, prednisone 30 rag/day, orally, given in 1-14 days. Treatment period of 21 days. 4 cycles or more for complete evaluation of the efficacy and side effects observed. Results： In 35 patients had 14 cases complete remission （CR） and 9 cases partial remission （PR）. The total efficiency was 65.7%. The main side effects were neutropenia, bone marrow suppression, alopecia and gastrointestinal reactions. Patients were all resistant to subject. Con- dusion： The IEBP is the treatment of relapsed or refractory non-Hodgkin＇s lymphoma safe and effective rescue plan and worthy of further promotion.

关 键 词：复发或难治性非霍奇金淋巴瘤 化疗 IEBP方案 异环磷酸胺 鬼臼乙叉甙 平阳霉素 泼尼松 

分 类 号：R551.2[医药卫生—血液循环系统疾病]