对硫糖铝制酸力检查方法的改进建议  

Improvement of Acid-neutralizing Capacity Test for Sucralfate

作　　者：王丽 申兰慧 陈国清 

机构地区：[1]江苏省无锡药品检验所,无锡214021

出　　处：《药学与临床研究》2012年第1期87-89,共3页Pharmaceutical and Clinical Research

摘　　要：目的:改进硫糖铝的制酸力检查法。方法:结合硫糖铝制酸速度的研究,探讨《中国药典》2010年版硫糖铝制酸力检查的振摇时间、振摇频率和终点指示方式对检测结果的影响。结果:将原标准硫酸铝制酸力检查的振摇时间缩短为20 min,振摇频率改为150次/min,且用电位法指示终点。结论:改进后的方法准确、可靠,可更有效地控制产品质量。Objective： To improve the acid-neutralizing capacity test for sucralfate and sucralfate tablets. Methods： Combined with the pharmacopeia standard of the acid-neutralizing rate of sucrelfate, the effects of the time and speed of vibration, methods of end-point indication on the acid-neutralizing capacity test were discussed. Results： The vibration lime was shorten to 20 rain at the speed of 150 r·min^-1. And the potentiometric method was recommended to indicate the end-point. Conclusion： This modified method is accurate, reliable and can control the quality of this product more effectively.

关 键 词：硫糖铝 制酸力 电位法 

分 类 号：R972.1[医药卫生—药品]