超声造影定量评价3-（5’-羟甲基-2’-呋喃基）-1-甲苯的治疗疗效  

Quantitative analysis of contrast-enhanced ultrasound in the evaluation of YC-1 effect

作　　者：张会萍[1] 李凡[1] 都伟丽[2] 史秋生[1] 杜联芳[1] 吴晴[2] 

机构地区：[1]上海交通大学附属第一人民医院超声科,200080 [2]上海交通大学附属第一人民医院肿瘤科,200080

出　　处：《中华实验外科杂志》2012年第3期398-400,共3页Chinese Journal of Experimental Surgery

基　　金：上海市级医院适宜技术联合开发推广应用项目（SHDC12010221）;上海市科委科技攻关计划资助项目（10411951800）

摘　　要：目的应用超声造影定量探讨3-（5’-羟甲基-2’-呋喃基）-1-甲苯（YC-1）治疗人胃癌裸鼠皮下移植瘤疗效的价值。方法建立人胃癌SGC7901／DDP细胞株裸鼠皮下移植瘤模型，将24只裸鼠随机分为4组：对照组（给予二甲基亚砜）、DDP组（给予顺铂）、YC-1组（给予YC-1）和YC-1＋DDP组（给予YC-1＋顺铂）。停药1周后行超声造影检查，应用SonoLiver进行定量分析。每一个肿瘤画2个感兴趣区：ROI。包含整个肿瘤，ROIsmall包含肿瘤中造影增强最强的部分。所得定量参数包括达峰时间（TTP）、上升时间（RT）、渡越时间（mTT）、达峰强度（Imax）、下降支斜率（R10、R20、R30）及上升支斜率（Vase）。结果ROIsmall及ROItotal试上，各超声造影定量参数在对照组与DDP之间以及在YC-1组与YC-1＋DDP组之间差异均无统计学意义（P〉0．05）。将裸鼠按照是否接受YC-1治疗重新分为YC-1治疗组及非YC-1治疗组。ROI训上，各超声造影定量参数在YC-1治疗组及非YC-1治疗组间差异均无统计学意义（P〉0．05）。ROIsmall上，与非YC-1治疗组相比，YC-1治疗组肿瘤达峰提前（TTP：5．47±0．93比8．05±2．00；RT：4．99±0．96比7．67±1．78，P〈0．05），造影剂消退快（mTT：37．49±19．51比98．94±60．97；R10：0．39±0．15比0．55±0．08；R20：0．30±0．10比0．43±0．10；R30：0．25±0．08比0．33±0．08，P〈0．05）。结论超声造影定量分析可有效评价YC-l对人胃癌裸鼠皮下移植瘤的治疗疗效，ROIsmall较ROItotal更适合用来评价肿瘤抗血管生成治疗的疗效。Objective To explore the value of contrast-enhanced ultrasound quantitative analysis in the evaluation of YC-1 effect on transplanted tumor of human gastric carcinoma in nude mice. Methods The transplanted tumor model of human gastric carcinoma in nude mice was established by injecting SGC7901/displatin （DDP） ceils into the subcutaneous space of 24 nude mice. The mice were randomized into four groups as control group （DMSO given）, DDP group （DDP given）, YC-1 group （YC-1 given） and YC-1 ± DDP group （both YC-1 and DDP given）. Contrast-enhanced ultrasound was performed one week after withdrawl and the dynamic image was analyzed quantitatively using SonoLiver software. For each tumor, two ROIs as ROI,o^a （including the total tumor） and ROI^1 （including the highest enhanced part of the tumor） were drawn and parameters including time-w-peak （TIP）, rise time （RT）, mean transit time （mTY）, max- imun intensity （ Imax）, R10, R20 and R30 （ descending velocity-the rate of intensity at TIP ± 10/20/30 s to Imax） and ascending velocity （Vase） were recorded for the statistical analysis. Results No parameter had significant difference between control group and DDP group or between YC-1 group and YC-1 ± DDP group in both ROIsmall and ROItotal （P 〉 0. 05 ）. The mice were regrouped into YC-1-treated-group and non-YC-1- treated-group. For ROIled, no parameter had significant difference between the two groups （ P 〉 0. 05 ）. For ROIsm^l, mierobubbles in YC-l-treated-group reached the peak earlier （ TIP ： 5.47 ± 0. 93 vs 8.05 ± 2. 00; RT： 4.99 ±0. 96 vs 7.67 ± 1.78 ,P 〈0. 05） and regressed faster （mTT：37.49 ± 19. 51 vs 98. 94 ± 60. 97; R10：0.39±0.15 vs0.55±0.08; R20 ： 0. 30 ± 0.10 vs0.43 ±0.10; R30：0.25 ±0.08 vs 0. 33 ± 0.08 ） than in non-YC-l-treated-group （ P 〈 0. 05 ）. Conclusion Contrast-enhanced ultrasound quantitative analysis could reflect the change of tumor blood supply after antiangiogenesis treatment. ROIsmall was more s

关 键 词：超声检查 造影剂 新生血管性 

分 类 号：R445.1[医药卫生—影像医学与核医学]