Zn2＋改性羧甲基纤维素预防术后腹膜粘连  

The Zn2＋ modifical sodium carboxymethyl cellulose on the prevention of postoperative abdominal adhesions

作　　者：刘国辉[1] 刘莉[4] 伦志军[2] 王广义[3] 

机构地区：[1]吉林大学白求恩第一医院急诊外科,长春130021 [2]吉林大学白求恩第一医院科教部,长春130021 [3]吉林大学白求恩第一医院普外科,长春130021 [4]吉林大学白求恩医学院法医学系

出　　处：《中华实验外科杂志》2012年第3期427-428,F0004,共3页Chinese Journal of Experimental Surgery

基　　金：长春市科技局基金资助项目（06GG112）;吉林大学创新课题项目（703016）

摘　　要：目的观察Zn2＋改性羧甲基纤维素（Zn2＋-SCMC）对术后腹腔粘连的预防作用。方法将90只大鼠随机分为A、B、C3组，每组各30只。先行均制作肠粘连模型，取A组腹腔内不放药物，B、C组于腹腔内损伤部位分别置人3ml、浓度3％的羧甲基纤维素（SCMC）及3ml、浓度3％的Zn2＋SCMC，术后10d处死大鼠，观察各组腹腔粘连情况。结果大鼠肠壁组织病理：A组纤维细胞增生明显，胶原纤维排列致密；B组纤维细胞增生较明显，胶原纤维排列略密；C组纤维细胞增生较轻，胶原纤维排列较疏松。术后10d腹腔内粘连情况：C组腹腔内轻微粘连，粘连发生率44．8％，B组中度粘连，粘连发生率80．0％，A组广泛粘连，致密，粘连发生率100．0％。A组Ⅲ～Ⅳ级粘连最多为17只，B组Ⅱ级粘连最多12只，C组0级粘连最多16只，C组粘连分级较B组、A组明显减轻，差异有统计学意义（P〈0．01）。结论Zn2＋-SCMC能明显减轻术后腹腔粘连程度，其作用优于SCMC。Objective To investigate the Zn2＋modifical sodium carboxymethyl cellulose （Zn2＋ SCMC） on the prevention of postoperative abdominal adhesion. Methods Ninety rats were randomly divid- ed into three groups： group A, group B and group C. They were first produced adhesions model. Then group A of drugs hold the abdominal cavity, but group B, group C were injected intra-abdominal at injured site 3% sodium carboxymethyl cellulose （SCMC） 3 ml, and 3%Zn2＋ -SCMC 3 ml separately. Each group was sacrificed on and abdominal adhesions were observed. Results Pathological change：group A was sig- nificantly more intestinal fibroblast proliferation, collagen fibers arranged in dense, group B was slight more intestinal fibroblast proliferation, collagen fibers arranged in slight dense;group C were less intestinal fibro- blast proliferation, collagen fibers Arranged in loose. The circumstance of abdominal adhesions after postop- erative 10 days： Group C minor intra-abdominal adhesions, the rate of abdominal adhesions is 44. 8%. Group B with moderate adhesion,the rate of abdominal adhesions is 80.0%. But group A extensive adhe- sions and dense, the rate of abdominal adhesions is 100. 0%. There are at most 17 rats on level m-IVadhe- sions of group A. There are at most 12 rats on level I1 adhesions of group B. And there are at most 16 rats on level 0 adhesions of group C. The adhesions grade of Group C obviously lighten than another two group. There is significant difference in adhesion grade （P 〈 0. 01 ）. Conclusion Zn2＋-SCMC significantly re- duce postoperative abdominal adhesions, its role is better than the SCMC.

关 键 词：羧甲基纤维素 腹腔粘连 预防 

分 类 号：R719.8[医药卫生—妇产科学]