MMP-2和MMP-9检测在急性冠状动脉综合征患者中的应用价值  

the Value of MMP-2 and MMP-9 Detected in Patients with Acute Coronary Syndrome

作　　者：王海波[1] 

机构地区：[1]四川省泸州市古蔺县人民医院内一科,四川泸州646000

出　　处：《中国医药指南》2012年第5期36-36,38,共2页Guide of China Medicine

摘　　要：目的探讨MMP-2和MMP-9检测在急性冠状动脉综合征患者中的临床应用价值。方法采用酶联免疫吸附试验(ELISA)法检测67例急性冠状动脉综合征患者的血清MMP-2和MMP-9,同时检测66例健康体检者作为对照组,并对检测结果进行统计分析。结果急性冠状动脉综合征患者组血浆MMP-2和MMP-9水平明显高于正常对照组,两组比较差异有统计学意义(P<0.05)。结论基质金属蛋白酶(MMPs)生化标志物参与动脉粥样硬化的进展及促进动脉粥样硬化板块的破裂,临床上检测MMP-2、MMP-9等生化标志物对预测和预后判断有重要的临床应用价值。Objective Of MMP-2 and MMP-9 detected in patients with acute coronary syndrome in the clinical application.Methods By enzyme-linked immunosorbent assay（ELISA） was detected 67 cases of acute coronary syndrome,serum MMP-2 and MMP-9,simultaneous detection of 66 cases of healthy persons as controls,and test results for statistical analysis.Results Plasma of patients with acute coronary syndrome MMP-2 and MMP-9 levels were significantly higher than the control group,the difference was statistically significant（P0.05）.Conclusion Matrix metalloproteinases（MMPs） involved in biochemical markers of atherosclerosis and to promote the progress of atherosclerosis plate rupture,the clinical detection of MMP-2,MMP-9 and other biochemical markers for the prediction and prognosis has important clinical applications value.

关 键 词：MMP-2 MMP-9 生化标志物 急性冠状动脉综合征 

分 类 号：R541.4[医药卫生—心血管疾病]