清热化痰活血法治疗痰瘀互结型痤疮疗效观察及对血清IL-4,IFN-γ的影响  

Clinical Observation of the Method of Removing Phlegm-Heat and Promoting Blood Circulation in Treating Acne with Phlegm Accumulate with Stagnant Blood Syndrome and Effect on Serum IL-4,IFN-γ

作　　者：张虹亚[1] 许光仓[1] 曹宇[1] 刘涛峰[1] 吴敏[1] 王建锋[1] 孙洪波[1] 

机构地区：[1]安徽中医学院第一附属医院(安徽省中医院)皮肤性病科,安徽合肥230031

出　　处：《中国皮肤性病学杂志》2012年第3期256-257,共2页The Chinese Journal of Dermatovenereology

摘　　要：目的观察清热化痰活血法对痰瘀互结型痤疮的临床疗效。方法 90例痰瘀互结型痤疮患者随机分为两组,治疗组51例用清热化痰活血方,1剂/d,水煎分2次服用,对照组39例口服丹参酮胶囊1g,3次/d,4周为一疗程,两组均治疗3个疗程。同时检测两组治疗前后血清IL-4,IFN-γ水平。结果治疗组有效率为49.02%,对照组41.02%,两组差异无统计学意义(P>0.05)。治疗后两组的IL-4,FN-γ均有不同的变化,IL-4水平降低,IFN-γ水平升高,与治疗前相比差异有统计学意义(P<0.01)。结论清热化痰活血法能明显改善痰瘀互结型痤疮患者的临床症状,降低IL-4水平,升高IFN-γ水平。Objective To observe the clinical effect of the method of removing phlegm-heat and promoting blood circulation in treating acne with phlegm accumulate with stagnant blood syndrome. Methods Ninety patients with phlegm accumulate with stagnant blood syndrome of acne were randomly divided into treatment group and control. 51 patients in treatment group were treated with the method of removing phlegm-heat and promoting Blood circulation, 39 patients in control group took danshentong capsule, the treatment duration was 12 weeks. The levels of serum IL-4 and IFN-γ were detected before and after the treatment. Results The total effective rate was 49.02% in treatment group, which was higher than that in the control group（41.02%）. There was no significant difference between the two groups （P 〉 0.05）. After the treatment , the level of IL-4 decreased and the level of IFN-γ increased significant in two groups （P 〈 0.01）. Conclusion Clinical effi cacy of the method of removing phlegm-heat and promoting Blood circulation was obvious, which can decrease the level of IL-4 and increase the level of IFN-γ.

关 键 词：清热化痰活血 痰瘀互结 痤疮 白细胞介素-4 干扰素-γ 

分 类 号：R758.73[医药卫生—皮肤病学与性病学]