糖调节受损脂联素基因SNP276多态性与代谢综合征异常组分数量的关系  

Association of SNP276 in adiponectin gene with complicating different component numbers of meta-bolic syndrome in population with impaired glucose regulation

作　　者：范雪梅[1] 

机构地区：[1]山西医学科学院山西大医院内分泌科,太原030001

出　　处：《中国医师杂志》2012年第1期13-15,19,共4页Journal of Chinese Physician

基　　金：：山西医科大学第二临床医院博士基金项目（20080413）

摘　　要：目的探讨中国山西地区汉族人群糖调节受损（IGR）脂联素基因单核苷酸多态性（SNP）276G／T与IGR合并代谢综合征异常组分数量的关系。方法采用聚合酶链反应一限制性内切酶长度多态性（PCR．RFLP）技术对无亲缘关系的山西地区汉族人群中256例IGR合并不同代谢综合征（MS）异常组分数量的患者，其中合并其他MS异常组分〈2项者为IGRA组，共123例，合并其他MS异常组分数量≥2项者为IGRB组，共133例；及113例体检正常的健康者为对照组的脂联素基因（APMl）SNP276进行基因分型，探讨其与IGR合并不同代谢综合征异常组分数量的关系。结果（1）脂联素基因SNP276G／T基因型及等位基因在对照组、IGRA组及IGRB组间总体分布差异有统计学意义（x。=16．893，P=O．002；~。=18．149，P=0．ooo）；（2）IGRA中GG＋GT型与TY型相比合并代谢综合征的风险未增加，经性别、年龄校正后，风险增加无统计学意义（P=0．781，P=0．809）；IGRB中GG＋GT型与TT型相比合并代谢综合征的风险增加，经性别、年龄校正后，风险增加均有统计学意义（P=0．007，P=0．007）。结论山西地区汉族人群糖调节受损者脂联素基因SNP276G／T可增加IGR合并代谢综合征异常组分的风险。Objective To study the association of SNP276 in adiponectin gene with impaired glu- cose regulation （IGR） complicating with the different component numbers of metabolism syndrome （MS） in population of IGR in Han people of Shanxi region. Methods The study population consisted of 256 sub- jects with IGR which was composed of 123 subjects with component numbers of MS 〈 2 （IGRA） and 133subjects with component numbers of MS≥2 （IGRB）, and 128 subjects with normal healthy （Normal） who were Chinese Hans residents and in Shanxi province. Polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） was applied to test the adiponectin SNP276G/T polymorphism. Results The distributions of genotypes and alleles of SNP276 both displayed significant difference among the three groups（X2 = 16. 893, P =0. 002 ;X2 = 18. 149, P = 0. 000）. In the IGRA, the SNP276 non-TY （GT ＋ GG） gen- otype was no difference which increased risk of complicating with the different component numbers of MS（ P =0.781, P =0. 809）. In IGRB , the SNP276 non-TT （GT ＋ GG） genotype was associated with increased risk of complicating with the different component numbers of MS, and after age and sex-adjusted, there was significant difference （ P =0. 007, P =0. 007）. Coneluslons SNP276 in APM1 increased the risk of c-omplicating with the components of MS in population with impaired glucose regulation in Han people of Shanxi region.

关 键 词：葡糖耐受不良/并发症/遗传学 血糖/代谢 脂联素/遗传学 代谢综合征X/并发 症/遗传学 多态性 单核苷酸 

分 类 号：R587.1[医药卫生—内分泌]