采用CGMS评价阿卡波糖对胰岛素治疗血糖波动的影响  

Evaluation of efficacy of acarbose by means of CGMS on blood glucose fluctuations during insulin therapy

作　　者：李晓静[1] 高政南[1] 程丽静[1] 牛敏[1] 李永航[1] 侯桂梅[1] 刘栩晗[1] 

机构地区：[1]大连市中心医院内分泌科,116003

出　　处：《中华内分泌代谢杂志》2012年第2期140-143,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：辽宁省自然科学基金资助项目（20082160）

摘　　要：62例2型糖尿病患者分别接受阿卡波糖联合胰岛素强化治疗（联合强化组）及单纯胰岛素强化治疗（单纯强化组）,当血糖控制达标时,联合强化组日内平均血糖波动幅度（MAGE）、日间平均血糖绝对差（MODD）、日平均血糖标准差（SDBG）明显低于单纯强化组[（3.76±1.47）对（6.52± 1.57） mmol/L,（0.57±0.49）对（1.10±0.69） mmol/L,（1.44±0.60）对（2.42±0.92）mmol/L,均P＜0.01].联合强化组日平均血糖（MBG）明显好于单纯强化组[（7.08±0.69）对8.27±1.31）mmol/L,P＜0.01]；疗程结束时联合强化组HbA1c水平好于单纯强化组（6.77％ -0.57％对7.21％±0.83％,P＜0.05）,低血糖发生率较少（29％对48％,P＜0.01）,体重指数较低[（24.14±2.7对27.63±3.41）kg/m2,P＜0.01].Sixty-two patients with type 2 diabetes were treated with acarbose combined intensive insulin therapy（ combined intensive group）or intensive insulin therapy alone （simple intensive group）.As the blood glucose control reached the target,the mean amplitude of glycaemic excursion （MAGE）,the absolute difference between the mean of daily differences （ MODD ）,and standard deviation of blood glucose （SDBG） in combined intensive group were lower than those in simple intensive group [ （ 3.76 ± 1.47 vs 6.52 ± 1.57 ） mmol/L,（ 0.57 ±0.49 vs 1.10 ±0.69 ）mmol/L,（ 1.44±0.60 vs 2.42±0.92 ） mmol/L,all P〈0.01 ].Daily mean blood glucose （MBG） of the former group was better than that of the latter group [ （7.08±0.69 vs 8.27 ± 1.31 ） mmol/L,P〈0.01 ].By the end of treatment,HbA1c [ 6.77% ± 0.57% vs 7.21% ±0.83%,P〈0.05 ],incidence of hypoglycemia（ 29% vs 48%,P〈0.01 ）,and body mass index[ （24.14±2.7 vs 27.63±3.41 ） kg/m2,P〈0.01 ] in combined intensive group were statistically improved more than those in the simple intensive group.

关 键 词：阿卡波糖 胰岛素强化治疗 糖尿病 2型 动态血糖监测 

分 类 号：R587.1[医药卫生—内分泌]