VEGFR3在自然妊娠和辅助生殖技术来源胎盘中的定位  

Location of VEGFR3 in the placenta subjected to natural pregnancy and assisted reproductive technology treatments

作　　者：汤丽莎[1] 张园 赵海君 骆秀翠[1] 高莉 崔毓桂[2] 刘嘉茵[2] 

机构地区：[1]连云港市妇幼保健院生育技术科,江苏省222006 [2]南京医科大学第一附属医院

出　　处：《江苏医药》2012年第4期425-427,共3页Jiangsu Medical Journal

基　　金：连云港市卫生局科教兴卫重点人才课题(ZC233);973项目(2006CB944005)

摘　　要：目的研究血管内皮生长因子受体(VEGFR)3在自然妊娠和辅助生殖技术(ART)来源胎盘的定位。方法收集ART来源(ART组,10例)和自然妊娠来源(对照组,11例)的单胎足月妊娠分娩的胎盘组织,分析两组流行病学资料并应用免疫组织化学染色研究VEGFR3在两组胎盘组织中的定位。结果 VEGFR3在两组胎盘组织中均定位于胎盘绒毛合体滋养层细胞细胞浆。结论 VEGFR3是胎盘组织中重要的血管生成调节因子,在胎盘组织中定位于胎盘绒毛合体滋养层细胞细胞浆,在ART组胎盘组织中的定位未见明显变化。Objective To study the location of vascular endothelial growth factor receptor 3 （VEGFR3） in the placenta subjected to natural pregnancy and assisted reproductive technology（ART） treatments. Methods Placenta tissues were collected from fulltime singletons of ART treatment （group ART, 10 cases）or normal pregnancies （group C, 11 cases）. The epidemiology data of all cases were analyzed. Immunohistochemistry was applied to study the location of VEGFR3 in the placenta. Results VEGFR3 was localized in the cytoplasm of syncytiotrophoblast cells in the placenta in both groups. Conclusion VEGFR3 is a critical angiogenic cytokine in the placenta. There is no variation in location of VEGFR3 in the placenta of ART.

关 键 词：血管内皮生长因子受体3 辅助生殖技术 胎盘 

分 类 号：R711[医药卫生—妇产科学]